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Assembly of PRR-containing receptors on scaffolds: a model for imidazoline I1-receptor action

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dc.contributor.authorMusgrave, I.
dc.contributor.authorDehle, F.
dc.contributor.authorPiletz, J.
dc.contributor.editorPiletz, J.E.
dc.contributor.editorRegunathan, S.
dc.contributor.editorErnsberger, P.
dc.date.issued2003
dc.descriptionThe definitive version is available at www.blackwell-synergy.com
dc.description.abstractIRAS, a putative clone of the I₁-imidazoline receptor, possesses a proline-rich region (PRR) motif, which might interact with SH3 regions on tyrosine kinases, and an integrin-binding motif. Receptors with a PRR motif can generally assemble onto multi-element signaling complexes (eg., the b₃-receptor on the EGF receptor) and thereby modulate signal transduction. Integrins serve as scaffolds for multi-element signaling complexes, similar to that assembled with the EGF receptor. It is therefore possible that IRAS signals through a complex with other receptors.
dc.identifier.citationAnnals of the New York Academy of Sciences, 2003; 1009(1):413-418
dc.identifier.doi10.1196/annals.1304.055
dc.identifier.issn0077-8923
dc.identifier.issn1749-6632
dc.identifier.orcidMusgrave, I. [0000-0003-1016-0588]
dc.identifier.urihttp://hdl.handle.net/2440/14288
dc.language.isoen
dc.publisherNew York Acad Sciences
dc.source.urihttp://www.annalsnyas.org/cgi/content/abstract/1009/1/413
dc.subjectimidazoline receptors
dc.subjectsignal transduction
dc.subjectintegrin
dc.subjectscaffold
dc.subjecttyrosine kinase
dc.subjectNischarin
dc.titleAssembly of PRR-containing receptors on scaffolds: a model for imidazoline I1-receptor action
dc.typeJournal article
pubs.publication-statusPublished

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