Repeated dose inhaled budesonide versus placebo in the treatment of croup

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dc.contributor.authorRoberts, G.
dc.contributor.authorMaster, V.
dc.contributor.authorStaugas, R.
dc.contributor.authorRaftos, J.
dc.contributor.authorParsons, D.
dc.contributor.authorCoulthard, K.
dc.contributor.authorMartin, A.
dc.date.issued1999
dc.description.abstractObjective: To investigate the efficacy and tolerance of 12-hourly dosing with 2 mg 4 mL–1 of inhaled budesonide versus placebo in patients admitted to hospital with moderate/severe croup. Method: Eighty-two children hospitalised with croup received either 2 mg 4 mL–1 of budesonide or placebo 12 hourly (maximum four doses) via Ventstream® nebuliser in a randomised, double-blind manner. Croup scores were performed at 0, 2, 6, 12, 24, 36 and 48 h from initial nebulisation whilst the patient remained hospitalised. Follow-up assessments were made 1 and 3 days after discharge. Results: Improvement was observed in the budesonide group over the 12-h dosing interval when compared to placebo (P = 0.04). Time to attain a significant clinical improvement was superior in the budesonide group (P = 0.01). Three days after discharge seven of 32 placebo-treated patients and one of 34 budesonide-treated patients had sought further medical follow-up (P = 0.02). Conclusion: Twelve-hourly dosing with inhaled budesonide significantly improved symptoms of croup as well as decreased relapse rates when compared with placebo.
dc.description.statementofresponsibilityGW Roberts, VV Master, RE Staugas, JV Raftos, DW Parsons, KP Coulthard and AJ Martin
dc.identifier.citationJournal of Paediatrics and Child Health, 1999; 35(2):170-174
dc.identifier.doi10.1046/j.1440-1754.1999.t01-1-00335.x
dc.identifier.issn1034-4810
dc.identifier.issn1440-1754
dc.identifier.orcidParsons, D. [0000-0002-8775-3501] [0000-0003-1746-3290]
dc.identifier.orcidMartin, A. [0000-0002-1606-5461]
dc.identifier.urihttp://hdl.handle.net/2440/7555
dc.language.isoen
dc.publisherBlackwell Science
dc.source.urihttps://doi.org/10.1046/j.1440-1754.1999.t01-1-00335.x
dc.subjectbudesonide
dc.subjectcroup
dc.subjectinhalation
dc.subjectrelapse
dc.titleRepeated dose inhaled budesonide versus placebo in the treatment of croup
dc.typeJournal article
pubs.publication-statusPublished

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