Aerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow

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dc.contributor.authorGemoets, H.P.L.
dc.contributor.authorHessel, V.
dc.contributor.authorNoël, T.
dc.date.issued2014
dc.description.abstractHerein, we report the first site-selective, Pd(II)-catalyzed, cross-dehydrogenative Heck reaction of indoles in micro flow. By use of a capillary microreactor, we were able to boost the intrinsic kinetics to accelerate former hour-scale reaction conditions in batch to the minute range in flow. The synergistic use of microreactor technology and oxygen, as both terminal oxidant and mixing motif, highlights the sustainable aspect of this process.
dc.description.statementofresponsibilityHannes P. L. Gemoets, Volker Hessel, and Timothy Noël
dc.identifier.citationOrganic Letters, 2014; 16(21):5800-5803
dc.identifier.doi10.1021/ol502910e
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.orcidHessel, V. [0000-0002-9494-1519]
dc.identifier.urihttp://hdl.handle.net/2440/129433
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.grantECHO 713.013.001
dc.relation.grantVENI 12464
dc.rights© 2014 American Chemical Society
dc.source.urihttps://doi.org/10.1021/ol502910e
dc.subjectOxygen
dc.subjectPalladium
dc.subjectAlkenes
dc.subjectIndoles
dc.subjectOxidants
dc.subjectMolecular Structure
dc.subjectKinetics
dc.subjectCatalysis
dc.subjectHydrogen Bonding
dc.titleAerobic C-H olefination of indoles via a cross-dehydrogenative coupling in continuous flow
dc.typeJournal article
pubs.publication-statusPublished

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