Influence of tumour grade on disease survival in male breast cancer patients: a systematic review.

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dc.contributor.authorKinsey-Trotman, S.
dc.contributor.authorNguyen, A.
dc.contributor.authorEdwards, S.
dc.contributor.authorSwalling, A.
dc.contributor.authorDasari, P.
dc.contributor.authorWalsh, D.
dc.contributor.authorIngman, W.V.
dc.date.issued2024
dc.description.abstractPurpose Histological grading of tumours is a well-established biomarker used to guide treatment in female breast cancer. However, its significance in male breast cancer remains unclear. This systematic review investigates the prognostic significance of tumour grade in relation to breast cancer-specific survival (BCSS) in male breast cancer patients undergoing surgery. Methods MEDLINE, PUBMED Central and EMBASE databases were searched to identify randomised trials and observational studies related to male breast neoplasms, tumour grading, recurrence, and survival. Results A total of fifteen observational type studies were included in the review. A significant association between tumour grade and BCSS was reported in a majority of studies. This association was most evident with regard to high-grade (grade III) compared to low grade (grade I) tumours, with a significant relationship in 4 out of 4 studies. For intermediate-grade II tumours an association was demonstrated in a minority of studies. Conclusions This study confirms an association between high-grade male breast cancers and poorer disease-specific survival, however, the significance of intermediate-grade tumours remains unclear. Further research is required to investigate the biology of male breast cancer in relation to histological grade and optimally define intermediate-grade disease.
dc.description.statementofresponsibilityStephen Kinsey, Trotman, Alain Nguyen, Suzanne Edwards, Adam Swalling, Pallave Dasari, David Walsh, Wendy V. Ingman
dc.identifier.citationBreast Cancer Research and Treatment, 2024; 208(1):1-8
dc.identifier.doi10.1007/s10549-024-07446-z
dc.identifier.issn0167-6806
dc.identifier.issn0167-6806
dc.identifier.orcidKinsey-Trotman, S. [0000-0003-4714-6659]
dc.identifier.orcidEdwards, S. [0000-0003-2074-1685]
dc.identifier.orcidDasari, P. [0000-0001-8399-1740]
dc.identifier.orcidIngman, W.V. [0000-0003-3116-2902]
dc.identifier.urihttps://hdl.handle.net/2440/144902
dc.language.isoen
dc.publisherSpringer
dc.rights© The Author(s) 2024.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.source.urihttp://dx.doi.org/10.1007/s10549-024-07446-z
dc.subjectMale breast cancer
dc.subjectPrognostic biomarker
dc.subjectSurvival
dc.subjectTumour grade
dc.subjectMale breast cancer; Tumour grade; Survival; Prognostic biomarker
dc.subject.meshHumans
dc.subject.meshBreast Neoplasms, Male
dc.subject.meshNeoplasm Recurrence, Local
dc.subject.meshPrognosis
dc.subject.meshMale
dc.subject.meshNeoplasm Grading
dc.titleInfluence of tumour grade on disease survival in male breast cancer patients: a systematic review.
dc.typeJournal article
pubs.publication-statusPublished online

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