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Novel Gd-loaded silicon nanohybrid: a potential epidermal growth factor receptor expressing cancer cell targeting magnetic resonance imaging contrast agent

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dc.contributor.authorSinha, S.
dc.contributor.authorTong, W.Y.
dc.contributor.authorWilliamson, N.H.
dc.contributor.authorMcInnes, S.J.P.
dc.contributor.authorPuttick, S.
dc.contributor.authorCifuentes Rius, A.
dc.contributor.authorBhardwaj, R.
dc.contributor.authorPlush, S.E.
dc.contributor.authorVoelcker, N.H.
dc.date.issued2017
dc.descriptionData source: Supporting information, http://pubs.acs.org/doi/abs/10.1021/acsami.7b14538
dc.description.abstractContinuing our research efforts in developing mesoporous silicon nanoparticle-based biomaterials for cancer therapy, we employed here porous silicon nanoparticles as a nanocarrier to deliver contrast agents to diseased cells. Nanoconfinement of small molecule Gd-chelates (L1-Gd) enhanced the T 1 contrast dramatically compared to distinct Gd-chelate (L1-Gd) by virtue of its slow tumbling rate, increased number of bound water molecules, and their occupancy time. The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on silicon nanostructures and conjugated to an antibody specific for epidermal growth factor receptor (EGFR) via a hydrazone linkage. The salient feature of this nanosized contrast agent is the capability of EGFR targeted delivery to cancer cells. Mesoporous silicon nanoparticles were chosen as the nanocarrier because of their high porosity, high surface area, and excellent biodegradability. This type of nanosized contrast agent also performs well in high magnetic fields.
dc.identifier.citationACS applied materials & interfaces, 2017; 9(49):42601-42611
dc.identifier.doi10.1021/acsami.7b14538
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.urihttps://hdl.handle.net/11541.2/130123
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.relation.fundingARC CE140100036 Centre of Excellence in Convergent Bio-Nano Science and Technology
dc.relation.fundingNHMRC 1112432
dc.relation.fundingCure Brain Cancer Foundation
dc.rightsCopyright 2017 American Chemical Society Access Condition Notes: Accepted manuscript available after 1 January 2019
dc.source.urihttps://doi.org/10.1021/acsami.7b14538
dc.subjectMRI
dc.subjectT₁ contrast agents
dc.subjectGd
dc.subjectporous silicon nanoparticles
dc.subjectEGFR
dc.titleNovel Gd-loaded silicon nanohybrid: a potential epidermal growth factor receptor expressing cancer cell targeting magnetic resonance imaging contrast agent
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12152828900001831 13151800080001831 ACS AMI_Sinha et al.pdf
ror.mmsid9916167888901831

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