Uptake and distribution of a platinum(II)-carborane complex within a tumour cell using synchrotron XRF imaging
Date
2011
Authors
Crossley, E.
Aitken, J.
Vogt, S.
Harris, H.
Rendina, L.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Australian Journal of Chemistry, 2011; 64(3):253-257
Statement of Responsibility
Ellen L. Crossley, Jade B. Aitken, Stefan Vogt, Hugh H. Harris and Louis M. Rendina
Conference Name
DOI
Abstract
Treatment of A549 human lung carcinoma cells with a DNA metallointercalator complex containing a PtII-terpy (terpy = 2,2′:6′,2′′-terpyridine) unit linked to a functionalized closo-carborane cage results in the uptake of the complex within the cells, as determined by synchrotron X-ray fluorescence (XRF) imaging. Although a significant cellular uptake of Pt existed, there was no significant accumulation of the element within the cell nuclei. Other statistically significant changes from the XRF data included an increase in Cl, K, and Cu and a decrease in Fe within the treated cells.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright CSIRO 2011