Impact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life

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dc.contributor.authorTalley, N.
dc.contributor.authorYoung, L.
dc.contributor.authorBytzer, P.
dc.contributor.authorHammer, J.
dc.contributor.authorLeemon, M.
dc.contributor.authorJones, M.
dc.contributor.authorHorowitz, M.
dc.date.issued2001
dc.descriptionThe definitive version is available at www.blackwell-synergy.com
dc.description.abstractOBJECTIVES: Morbidity from GI symptoms in diabetes is considered to be high, but no studies have quantified the impact of GI symptoms in diabetes on health-related quality of life. We hypothesized that diabetics reporting increased GI symptoms would experience more impaired quality of life. METHODS: Subjects from the community with diabetes (n = 892) and outpatients with diabetes (n = 209) were recruited for this study. Subjects were divided into type 1 (diabetes diagnosed at age <30 yr and requiring insulin) and type 2. A validated questionnaire measuring GI symptoms and diabetes status and the Short Form-36 were completed. The results were compared with Australian normal data. GI symptom groups measured were frequent abdominal pain, bowel-related abdominal pain, reflux, dyspepsia, constipation, diarrhea, and fecal incontinence. RESULTS: There was a clinically significant decrease in quality-of-life scores in diabetics compared with population norms across all subscales. The impact on quality of life in diabetes was predominantly observed in type 2 diabetics. The quality-of-life scores in all subscales decreased markedly with increasing numbers of distinct GI symptom groups, and this was similar in community and outpatient diabetics. For all the Short Form-36 subscales, GI symptom groups were significantly (all p < 0.0001) associated with poorer quality of life in diabetes, independent of age, gender, smoking, alcohol use, and type of diabetes. CONCLUSIONS: GI symptoms impact negatively on health-related quality of life in diabetes mellitus.
dc.description.statementofresponsibilityNicholas J. Talley, Lisa Young, Peter Bytzer, Johann Hammer, Melanie Leemon, Michael Jones, and Michael Horowitz
dc.identifier.citationAmerican Journal of Gastroenterology, 2001; 96(1):71-76
dc.identifier.doi10.1111/j.1572-0241.2001.03350.x
dc.identifier.issn0002-9270
dc.identifier.issn1572-0241
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.urihttp://hdl.handle.net/2440/39103
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.rights© 2001 The American College of Gastroenterology
dc.source.urihttps://doi.org/10.1111/j.1572-0241.2001.03350.x
dc.subjectHumans
dc.subjectGastrointestinal Diseases
dc.subjectDiabetes Mellitus, Type 1
dc.subjectDiabetes Mellitus, Type 2
dc.subjectChronic Disease
dc.subjectHealth Surveys
dc.subjectPrevalence
dc.subjectAnalysis of Variance
dc.subjectProbability
dc.subjectRisk Factors
dc.subjectComorbidity
dc.subjectAge Distribution
dc.subjectSex Distribution
dc.subjectQuality of Life
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectSurveys and Questionnaires
dc.titleImpact of chronic gastrointestinal symptoms in diabetes mellitus on health-related quality of life
dc.typeJournal article
pubs.publication-statusPublished

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