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Dietary calcium, magnesium, and phosphorus intakes and risk of stroke in Chinese adults

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dc.contributor.authorZhu, H.L.
dc.contributor.authorLiu, Y.
dc.contributor.authorZhang, J.
dc.contributor.authorWang, M.X.
dc.contributor.authorJiang, H.
dc.contributor.authorGuo, F.
dc.contributor.authorLi, M.
dc.contributor.authorQi, F.F.
dc.contributor.authorLiu, X.H.
dc.contributor.authorMa, L.
dc.date.issued2021
dc.descriptionData source: Supplementary information, https://doi.org/10.1038/s41598-021-90388-z
dc.description.abstractControversial results have been reported about the association of calcium, magnesium, and phosphorus and stroke risk, but none in China. To investigate the association between dietary calcium, magnesium, phosphorus, and stroke incidence in Chinese adults, we collected data from the China Health and Nutrition Survey (CHNS) from 2004 to 2011, including 6411 participants aged 45–79 years and free of stroke at baseline. Diet was assessed by interviews combining 3-d 24-h food recalls and household food inventory weighing at each survey round. The stroke incident was identified based on the validated self-report. Multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). For 32,024 person-years of follow-up, 179 stroke cases were documented. After adjustment for major lifestyle and dietary risk factors, calcium intake was positively associated with reduced stroke risk, and the HR of stroke comparing extreme quartiles was 0.53 (95% CI 0.29–0.96, Ptrend = 0.03). In further stratified analyses, significant heterogeneity across sex strata was found (Pinteraction = 0.03). Dietary calcium intake among men was more inversely related to stroke, with HRs being 0.33 (95% CI 0.15–0.76, Ptrend = 0.02), compared to 1.24 (95% CI 0.46–3.35, Ptrend = 0.89) among women. However, no significant association between stroke and magnesium or phosphorus was revealed. Our findings suggest that higher dietary calcium intake was associated with a lower risk of stroke in Chinese adults, particularly in men
dc.identifier.citationScientific Reports, 2021; 11(1, article no. 11270):1-9
dc.identifier.doi10.1038/s41598-021-90388-z
dc.identifier.issn2045-2322
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11541.2/148085
dc.language.isoen
dc.publisherNature Publishing Group
dc.relation.fundingNational Institutes of Health
dc.rightsCopyright 2021 The author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. (http://creativecommons.org/licenses/by/4.0/)
dc.source.urihttps://doi.org/10.1038/s41598-021-90388-z
dc.subjectdiet
dc.subjectChinese adults
dc.subjectstroke incidence
dc.subjecthousehold food inventory
dc.titleDietary calcium, magnesium, and phosphorus intakes and risk of stroke in Chinese adults
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12229791610001831 13229791600001831 s41598-021-90388-z.pdf
ror.mmsid9916527709301831

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