Systemic infusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats

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dc.contributor.authorSteeb, C.B.
dc.contributor.authorShoubridge, C.
dc.contributor.authorTivey, D.
dc.contributor.authorRead, L.
dc.date.issued1997
dc.description.abstractThis study describes developmental changes in gastrointestinal response to insulin-like growth factor I (IGF-I) peptide administration. Neonatal rats were infused with IGF-I or long [Arg3]IGF-I (LR(3)IGF-I) for 6.5 days starting on day 6 or 12 postpartum. Peptides were delivered by mini osmotic pumps at 0, 2, 5, or 12.5 microg x g(-1) x day(-1). IGF-I infusion increased plasma IGF-I levels in both age groups but stimulated body weight gain only in the older rats. Infusion of LR(3)IGF-I did not change plasma IGF-I levels. Both peptides enhanced expression of IGF-binding proteins (IGFBP) 1 and 2 and induced IGFBP-3 in the older rats. For both age groups, weights of the kidney and spleen increased by up to 85 and 76%, respectively. IGF-I treatment also stimulated gut weight and length by up to 60 and 32%, respectively, but dose dependency was observed only in the older rats. LR(3)IGF-I was more potent for all growth parameters in both age groups. Histological observations included thickening of the mucosa and muscularis externa after infusion of IGF-I peptides. Thymidine labeling in the younger rats indicated that proliferative activity increased proportionately with crypt cell growth. These results show that IGF-I peptides selectively stimulate growth of gastrointestinal tissues in suckling rats and that the proximal gut was the most peptide-responsive region.
dc.identifier.citationAmerican Journal of Physiology, 1997; 272(3 Pt 1):G522-G533
dc.identifier.doi10.1152/ajpgi.1997.272.3.G522
dc.identifier.issn0002-9513
dc.identifier.issn2163-5773
dc.identifier.orcidShoubridge, C. [0000-0002-0157-3084]
dc.identifier.orcidTivey, D. [0000-0003-2213-2576]
dc.identifier.urihttp://hdl.handle.net/2440/6945
dc.language.isoen
dc.publisherAMER PHYSIOLOGICAL SOC
dc.source.urihttps://doi.org/10.1152/ajpgi.1997.272.3.g522
dc.subjectIntestines
dc.subjectIntestinal Mucosa
dc.subjectDuodenum
dc.subjectIleum
dc.subjectAnimals
dc.subjectAnimals, Suckling
dc.subjectRats
dc.subjectInsulin
dc.subjectInsulin-Like Growth Factor I
dc.subjectInsulin-Like Growth Factor Binding Proteins
dc.subjectOrgan Size
dc.subjectAge Factors
dc.subjectCell Division
dc.subjectMolecular Weight
dc.titleSystemic infusion of IGF-I or LR(3)IGF-I stimulates visceral organ growth and proliferation of gut tissues in suckling rats
dc.typeJournal article
pubs.publication-statusPublished

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