Bone remodelling inflammatory arthritis

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dc.contributor.authorGoldring, S.
dc.contributor.authorPurdue, P.
dc.contributor.authorCrotti, T.
dc.contributor.authorShen, Z.
dc.contributor.authorFlannery, M.
dc.contributor.authorBinder, N.
dc.contributor.authorRoss, F.
dc.contributor.authorMcHugh, K.
dc.date.issued2013
dc.description.abstractThe inflammatory arthropathies that include rheumatoid arthritis, the seronegative spondyloarthropathies and systemic lupus erythematosus are characterised by marked alterations in the architecture and structural integrity of peri-articular bone; however, the pattern and natural history of the skeletal changes differs in these conditions. In part, this can be attributed to differences in the primary anatomical site of the inflammation, but also there is evidence that there are differences in the biological properties and products produced by inflammatory tissues. This review will focus on recent advances in the understanding of the cellular and molecular mechanisms that contribute to the differential pattern of articular bone remodelling in these prototypical inflammatory forms of arthritis.
dc.description.statementofresponsibilitySteven R. Goldring, P. Edward Purdue, Tania N. Crotti, Zhenxin Shen, Merrilee R. Flannery, Nikolaus B. Binder, F. Patrick Ross and Kevin P. McHugh
dc.identifier.citationAnnals of the Rheumatic Diseases, 2013; 72(suppl 2):52-55
dc.identifier.doi10.1136/annrheumdis-2012-202199
dc.identifier.issn0003-4967
dc.identifier.issn1468-2060
dc.identifier.orcidCrotti, T. [0000-0002-5422-3758]
dc.identifier.urihttp://hdl.handle.net/2440/77205
dc.language.isoen
dc.publisherBMJ Publishing Group
dc.rightsCopyright © 2013 BMJ Publishing Group Ltd & European League Against Rheumatism. All rights reserved.
dc.source.urihttps://doi.org/10.1136/annrheumdis-2012-202199
dc.subjectOsteoclasts
dc.subjectHumans
dc.subjectSpondylarthropathies
dc.subjectArthritis, Rheumatoid
dc.subjectLupus Erythematosus, Systemic
dc.subjectBone Remodeling
dc.titleBone remodelling inflammatory arthritis
dc.typeJournal article
pubs.publication-statusPublished

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