A comparison of the disease-modifying and cytokine-regulating activities of tenidap, piroxicam and cyclosporin-A using the adjuvant-induced model of arthritis in rats

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dc.contributor.authorHaynes, D.
dc.contributor.authorHutchens, M.
dc.contributor.authorWhitehouse, M.
dc.contributor.authorVernon-Roberts, B.
dc.date.issued1998
dc.description.abstractThis study compared the antiarthritic activity of tenidap, piroxicam and cyclosporin-A (CsA) using the model of adjuvant-induced arthritis in rats. The aim of the study was to correlate any disease-modifying effects of tenidap with its in-vivo regulation of cytokines. Both tenidap and piroxicam reduced arthritic disease when administered orally from the time the first signs of arthritis are expressed. Disease suppression correlated with a significant reduction in interleukin-6 production and a slight reduction in interleukin-1 and tumour necrosis factor production. When coadministered with the adjuvant, tenidap and CsA prevented disease in 50% and 100% of animals, respectively, whereas piroxicam had no effect. This disease prevention induced by tenidap and CsA coincided with reduced interferon-γ and interleukin-2 production by lymph node cells one day following initiation of adjuvant disease. This inhibition of T-cell cytokines might be consistent with tenidap acting as a disease-modifying drug.
dc.description.statementofresponsibilityD. R. Haynes, M. J. Hutchens, M. W. Whitehouse, B. Vernon-Roberts
dc.identifier.citationInflammopharmacology: experimental and clinical studies, 1998; 6(3):193-202
dc.identifier.doi10.1007/s10787-998-0019-z
dc.identifier.issn0925-4692
dc.identifier.issn1568-5608
dc.identifier.urihttp://hdl.handle.net/2440/5644
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.rights© Springer, Part of Springer Science+Business Media
dc.source.urihttps://doi.org/10.1007/s10787-998-0019-z
dc.titleA comparison of the disease-modifying and cytokine-regulating activities of tenidap, piroxicam and cyclosporin-A using the adjuvant-induced model of arthritis in rats
dc.typeJournal article
pubs.publication-statusPublished

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