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The role of zinc in genomic stability

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dc.contributor.authorSharif, R.
dc.contributor.authorThomas, P.
dc.contributor.authorZalewski, P.
dc.contributor.authorFenech, M.
dc.date.issued2012
dc.description.abstractZinc (Zn) is an essential trace element required for maintaining both optimal human health and genomic stability. Zn plays a critical role in the regulation of DNA repair mechanisms, cell proliferation, differentiation and apoptosis involving the action of various transcriptional factors and DNA or RNA polymerases. Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle. This review focuses on the role of Zn in the maintenance of genome integrity and the effects of deficiency or excess on genomic stability events and cell death.
dc.description.statementofresponsibilityRazinah Sharif, Philip Thomas, Peter Zalewski and Michael Fenech
dc.identifier.citationMutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 2012; 733(1-2):111-121
dc.identifier.doi10.1016/j.mrfmmm.2011.08.009
dc.identifier.issn1386-1964
dc.identifier.issn0027-5107
dc.identifier.orcidZalewski, P. [0000-0001-5196-2611]
dc.identifier.orcidFenech, M. [0000-0002-8466-0991]
dc.identifier.urihttp://hdl.handle.net/2440/71244
dc.language.isoen
dc.publisherElsevier Science BV
dc.relation.isreplacedby2440/89947
dc.relation.isreplacedbyhttp://hdl.handle.net/2440/89947
dc.rights© 2011 Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.mrfmmm.2011.08.009
dc.subjectCell Line
dc.subjectTelomere
dc.subjectAnimals
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectDNA Damage
dc.subjectGenomic Instability
dc.subjectZinc
dc.subjectTrace Elements
dc.subjectAntioxidants
dc.subjectDNA Methylation
dc.subjectDNA Repair
dc.subjectOxidative Stress
dc.subjectDose-Response Relationship, Drug
dc.subjectPolymorphism, Genetic
dc.titleThe role of zinc in genomic stability
dc.typeJournal article
pubs.publication-statusPublished

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