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Erythromycin improves gastric emptying in critically ill patients intolerant of nasogastric feeding

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dc.contributor.authorChapman, M.
dc.contributor.authorFraser, R.
dc.contributor.authorKluger, M.
dc.contributor.authorBuist, M.
dc.contributor.authorDe Nichilo, D.
dc.date.issued2000
dc.description.abstract<h4>Objective</h4>To evaluate the effect of intravenous erythromycin on gastric emptying and the success of enteral feeding in mechanically ventilated, critically ill patients with large volume gastric aspirates.<h4>Design</h4>Prospective, double-blind, randomized, and placebo-controlled trial.<h4>Setting</h4>General intensive care unit in a university hospital.<h4>Patients</h4>Twenty critically ill, mechanically ventilated patients intolerant of nasogastric feeding (indicated by a residual gastric volume of > or =250 mL during feed administration at > or =40 mL/hr).<h4>Interventions</h4>After a gastric aspirate of > or =250 mL, which was discarded, the enteral feeding was continued at the previous rate for 3 hrs. Intravenous erythromycin (200 mg) or placebo was then administered over 20 mins. The residual gastric contents were again aspirated and the volume was recorded 1 hr after the infusion began.<h4>Measurements and main results</h4>Gastric emptying was calculated as volume of feed infused into the stomach over 4 hrs minus the residual volume aspirated. Mean gastric emptying was 139+/-37 (+/-SEM) mL after erythromycin and -2+/-46 mL after placebo (p = .027). Nasogastric feeding was successful in nine of ten patients treated with erythromycin and five of ten who received placebo 1 hr after infusion (chi-square p = .05).<h4>Conclusion</h4>In critically ill patients who have large volumes of gastric aspirates indicating a failure to tolerate nasogastric feeding, a single small dose of intravenous erythromycin allows continuation of feed in the short term.
dc.description.statementofresponsibilityChapman, Marianne J.; Fraser, Robert J.; Kluger, Michal T.; Buist, Michael D.; De Nichilo, Daniela J.
dc.identifier.citationCritical Care Medicine, 2000; 28(7):2334-2337
dc.identifier.doi10.1097/00003246-200007000-00026
dc.identifier.issn0090-3493
dc.identifier.issn1530-0293
dc.identifier.orcidChapman, M. [0000-0003-0710-3283]
dc.identifier.urihttp://hdl.handle.net/2440/9382
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.rightsCopyright: © 2000 Lippincott Williams & Wilkins, Inc.
dc.source.urihttps://doi.org/10.1097/00003246-200007000-00026
dc.subjectHumans
dc.subjectErythromycin
dc.subjectGastrointestinal Agents
dc.subjectRespiration, Artificial
dc.subjectEnteral Nutrition
dc.subjectCritical Care
dc.subjectInfusions, Intravenous
dc.subjectAPACHE
dc.subjectDouble-Blind Method
dc.subjectIntubation, Gastrointestinal
dc.subjectGastric Emptying
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.titleErythromycin improves gastric emptying in critically ill patients intolerant of nasogastric feeding
dc.typeJournal article
pubs.publication-statusPublished

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