pH-Responsive Biomaterials for the Treatment of Dental Caries - A Focussed and Critical Review

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dc.contributor.authorHe, Y.
dc.contributor.authorVasilev, K.
dc.contributor.authorZilm, P.
dc.date.issued2023
dc.description.abstractDental caries is a common and costly multifactorial biofilm disease caused by cariogenic bacteria that ferment carbohydrates to lactic acid, demineralizing the inorganic component of teeth. Therefore, low pH (pH 4.5) is a characteristic signal of the localised carious environment, compared to a healthy oral pH range (6.8 to 7.4). The development of pH-responsive delivery systems that release antibacterial agents in response to low pH has gained attention as a targeted therapy for dental caries. Release is triggered by high levels of acidogenic species and their reduction may select for the establishment of health-associated biofilm communities. Moreover, drug efficacy can be amplified by the modification of the delivery system to target adhesion to the plaque biofilm to extend the retention time of antimicrobial agents in the oral cavity. In this review, recent developments of different pH-responsive nanocarriers and their biofilm targeting mechanisms are discussed. This review critically discusses the current state of the art and innovations in the development and use of smart delivery materials for dental caries treatment. The authors’ views for the future of the field are also presented.
dc.description.statementofresponsibilityYanping He, Krasimir Vasilev, and Peter Zilm
dc.identifier.citationPharmaceutics, 2023; 15(7):1837-1837
dc.identifier.doi10.3390/pharmaceutics15071837
dc.identifier.issn1999-4923
dc.identifier.issn1999-4923
dc.identifier.orcidHe, Y. [0000-0003-4784-5812]
dc.identifier.orcidZilm, P. [0000-0001-7554-9717]
dc.identifier.urihttps://hdl.handle.net/2440/139253
dc.language.isoen
dc.publisherMDPI AG
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/GNT1194466
dc.rights© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.3390/pharmaceutics15071837
dc.subjectpH-responsive delivery systems; pH-responsive release mechanism; tooth-binding; dental caries
dc.titlepH-Responsive Biomaterials for the Treatment of Dental Caries - A Focussed and Critical Review
dc.typeJournal article
pubs.publication-statusPublished

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