One stop lab on chip platform for tissue processing and cell sample preparation
Date
2016
Authors
Al Mofty, S.
El Badri, N.
Altayyeb, A.
Omar, O.
Elsayed, M.
Wahbi, A.
Ali, H.
Abdelgawad, M.
Mousa, N.
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Type:
Conference paper
Citation
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, 2016, pp.1553-1554
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Conference Name
20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (9 Oct 2016 - 13 Oct 2016 : Dublin, Ireland)
Abstract
Current tissue processing methods are quite invasive; involving cutting, mincing, and enzymatic dissociation. This is further followed by several independent and manual steps including cell sieving, washing, pipetting and centrifugation, resulting in significant loss of cells, which is not appropriate for rare cells such as cancer stem cells, and adult stem cells. Here, we present a microfluidics tissue processing platform that encompasses successive steps of tissue dissociation, debris filtration, cell sieving and washing, cell trapping, staining, and counting; all on one integrated device.
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Copyright 2016 Chemical and Biological Microsystems Society