Synthesis and biological activity of allosteric modulators of GABA(B) receptors, Part 1. N-(phenylpropyl)-1-arylethylamines
Date
2006
Authors
Kerr, D.
Ong, J.
Perkins, M.
Prager, R.
Puspawati, N.
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Type:
Journal article
Citation
Australian Journal of Chemistry, 2006; 59(7):445-456
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Abstract
<jats:p>A series of 15 analogues of fendiline, and 34 derivatives of N-(3-phenylpropyl)-1-arylethylamine have been prepared for evaluation as positive allosteric modulators of GABAB receptors. The most active (EC50, 10 nM) was N-(3,3-diphenylpropyl)-1-(3-chloro-4-methoxyphenyl)ethylamine 6g.</jats:p>