Alzheimer disease: amyloidogenesis, the presenilins and animal models

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dc.contributor.authorNewman, M.
dc.contributor.authorMusgrave, I.
dc.contributor.authorLardelli, M.
dc.contributor.organisationCentre for the Molecular Genetics of Development
dc.date.issued2007
dc.description.abstractAlzheimer’s disease is the most prevalent form of dementia. Neuropathogenesis is proposed to be a result of the accumulation of amyloid beta peptides in the brain together with oxidative stress mechanisms and neuroinflammation. The presenilin proteins are central to the gamma-secretase cleavage of the amyloid prescursor protein (APP), releasing the amyloid beta peptide. Point mutations in the presenilin genes lead to cases of familial Alzheimer’s disease by increasing APP cleavage resulting in excess amyloid beta formation. This review discusses the molecular mechanism of Alzheimer’s disease with a focus on the presenilin genes. Alternative splicing of transcripts from these genes and how these may function in several disease states is discussed. There is an emphasis on the importance of animal models in elucidating the molecular mechanisms behind the development of Alzheimer’s disease and how the zebrafish, Danio rerio, can be used as a model organism for analysis of presenilin function and Alzheimer’s disease pathogenesis.
dc.identifier.citationBiochimica et Biophysica Acta - Molecular Basis of Disease, 2007; 1772(3):285-297
dc.identifier.doi10.1016/j.bbadis.2006.12.001
dc.identifier.issn0925-4439
dc.identifier.issn0167-4889
dc.identifier.orcidNewman, M. [0000-0002-4930-4529]
dc.identifier.orcidMusgrave, I. [0000-0003-1016-0588]
dc.identifier.orcidLardelli, M. [0000-0002-4289-444X]
dc.identifier.urihttp://hdl.handle.net/2440/43025
dc.language.isoen
dc.publisherElsevier Science BV
dc.source.urihttps://doi.org/10.1016/j.bbadis.2006.12.001
dc.subjectAlzheimer’s disease
dc.subjectAmyloid-beta
dc.subjectAnimal models
dc.subjectOxidative stress
dc.subjectPresenilin
dc.subjectZebrafish
dc.titleAlzheimer disease: amyloidogenesis, the presenilins and animal models
dc.typeJournal article
pubs.publication-statusPublished

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