Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair

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dc.contributor.authorAhangar, P.
dc.contributor.authorMills, S.J.
dc.contributor.authorCowin, A.J.
dc.date.issued2020
dc.description.abstractThe use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cytokines, referred to as the MSC secretome, that has considerable potential for the treatment of cutaneous wounds as a cell-free therapy. In this review, we outline the current status of MSCs as a treatment for cutaneous wounds and introduce the potential of the MSC secretome as a cell-free alternative for wound repair. We discuss the challenges and provide insights and perspectives for the future development of the MSC secretome as well as identify its potential clinical translation into a therapeutic treatment.
dc.description.statementofresponsibilityParinaz Ahangar, Stuart J. Mills and Allison J. Cowin
dc.identifier.citationInternational Journal of Molecular Sciences, 2020; 21(19):1-15
dc.identifier.doi10.3390/ijms21197038
dc.identifier.issn1422-0067
dc.identifier.issn1422-0067
dc.identifier.orcidCowin, A.J. [0000-0003-2885-2080]
dc.identifier.urihttp://hdl.handle.net/2440/129036
dc.language.isoen
dc.publisherMDPI AG
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1002009
dc.rights© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.source.urihttps://doi.org/10.3390/ijms21197038
dc.subjectmesenchymal stem cells
dc.subjectsecretome
dc.subjectwound healing
dc.titleMesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair
dc.typeJournal article
pubs.publication-statusPublished

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