TGF-β signalling and immunity in prostate tumourigenesis

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dc.contributor.authorDiener, K.
dc.contributor.authorNeed, E.
dc.contributor.authorBuchanan, G.
dc.contributor.authorHayball, J.
dc.date.issued2010
dc.description.abstract<h4>Importance of the field</h4>The TGF-beta's are pleiotropic cytokines that regulate multiple cellular functions. Their role in the prostate is important for normal prostate development and also in prostate tumourigenesis.<h4>Areas covered in this review</h4>The interactions TGF-beta-mediated signalling has with maintaining prostate health, as well as its role in prostate tumourigenesis and prostate tumour immune evasion, with emphasis on how a breakdown in these interactions may influence disease progression.<h4>What the reader will gain</h4>That TGF-beta influences normal prostate growth and differentiation by regulating the balance between epithelial cell proliferation and apoptosis, and involving the androgen receptor pathway. That TGF-beta protects and maintains prostate stem cells and a review of the contrasting role TGF-beta has in prostate tumourigenesis and tumour development, where TGF-beta acts as a tumour suppressor and then switches roles to become a tumour promoter, and creates a local immunosuppressive niche leading to systemic tumour tolerance.<h4>Take home message</h4>TGF-beta signalling in prostate cancer is a valid target for the treatment of this disease; however any therapeutic regimen will require an understanding of all aspects of the TGF-beta-signalling nexus, otherwise by the very pleiotrophic nature of TGF-beta, limited clinical benefits may result.
dc.description.statementofresponsibilityKerrilyn R. Diener, Eleanor F. Need, Grant Buchanan & John D. Hayball
dc.identifier.citationExpert Opinion on Therapeutic Targets, 2010; 14(2):179-192
dc.identifier.doi10.1517/14728220903544507
dc.identifier.issn1472-8222
dc.identifier.issn1744-7631
dc.identifier.orcidDiener, K. [0000-0001-8417-5542]
dc.identifier.orcidHayball, J. [0000-0002-3089-4506]
dc.identifier.urihttp://hdl.handle.net/2440/59757
dc.language.isoen
dc.publisherInforma Healthcare
dc.rights© 2010 Informa UK Ltd
dc.source.urihttps://doi.org/10.1517/14728220903544507
dc.subjectandrogen receptor, immunosuppression, prostate cancer, stem cells, TGF-β
dc.titleTGF-β signalling and immunity in prostate tumourigenesis
dc.title.alternativeTGF-beta signalling and immunity in prostate tumourigenesis
dc.typeJournal article
pubs.publication-statusPublished

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