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The impact of intensified exercise training on insulin resistance and fitness in overweight and obese women with and without polycystic ovary syndrome

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dc.contributor.authorHarrison, C.L.
dc.contributor.authorStepto, N.K.
dc.contributor.authorHutchison, S.K.
dc.contributor.authorTeede, H.J.
dc.date.issued2012
dc.description.abstractObjective: To evaluate mechanisms of insulin resistance (IR) in overweight and obese women with and without polycystic ovary syndrome (PCOS) and explore relationships between IR, fitness and body mass index (BMI) at baseline and following exercise intervention. Design: Prospective controlled intensified exercise intervention study. Patients: A total of 20 overweight (BMI > 25 kg/m2) and obese (>30 kg/m2), reproductive‐aged PCOS women and 13 non‐PCOS overweight, healthy controls of comparable BMI and age were studied at baseline. Measures were repeated in 13 PCOS and eight control women following three 1‐h exercise sessions per week over 12 weeks. Measurements: Insulin resistance was measured by glucose infusion rate on euglycaemic hyperinsulinaemic clamp, and fitness was assessed by VO2max. Results: At baseline, PCOS women were 46% more insulin resistant than controls (175·6 vs 257·2 mg/m2/min, P < 0·05) with IR independently associated with VO2max and BMI in the PCOS group only (P < 0·01). Postexercise IR improved across both groups (P < 0·01). In PCOS women, IR improved by 16% (P < 0·05) but was not restored to the same level as controls (P < 0·05). Improvement in IR and in VO2max was related to the PCOS group (r2 = 0·85, P < 0·05), yet change in IR and in fitness was not related. No associations were found in controls. Conclusions: While intensified exercise improves IR in PCOS women, a higher IR persisted following exercise in PCOS women, and a clear relationship between improved IR and improved fitness was not found. Therefore, other mechanisms of, and therapies for, IR must be explored in PCOS as IR remains higher than observed in non‐PCOS controls.
dc.description.statementofresponsibilityCheryce L. Harrison, Nigel K. Stepto, Samantha K. Hutchison, Helena J. Teede
dc.identifier.citationClinical Endocrinology, 2012; 76(3):351-357
dc.identifier.doi10.1111/j.1365-2265.2011.04160.x
dc.identifier.issn0300-0664
dc.identifier.issn1365-2265
dc.identifier.orcidTeede, H.J. [0000-0001-7609-577X]
dc.identifier.urihttp://hdl.handle.net/2440/118901
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/606553
dc.rights© 2012 Blackwell Publishing Ltd.
dc.source.urihttps://doi.org/10.1111/j.1365-2265.2011.04160.x
dc.subjectHumans
dc.subjectPolycystic Ovary Syndrome
dc.subjectInsulin Resistance
dc.subjectObesity
dc.subjectBlood Glucose
dc.subjectExercise Test
dc.subjectBody Mass Index
dc.subjectGlucose Clamp Technique
dc.subjectExercise
dc.subjectAnalysis of Variance
dc.subjectLinear Models
dc.subjectProspective Studies
dc.subjectOxygen Consumption
dc.subjectTime Factors
dc.subjectAdult
dc.subjectFemale
dc.subjectOverweight
dc.titleThe impact of intensified exercise training on insulin resistance and fitness in overweight and obese women with and without polycystic ovary syndrome
dc.typeJournal article
pubs.publication-statusPublished

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