Early pregnancy maternal endocrine insulin-like growth factor I programs the placenta for increased functional capacity throughout gestation

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dc.contributor.authorSferruzzi-Perri, A.
dc.contributor.authorOwens, J.
dc.contributor.authorStanden, P.
dc.contributor.authorTaylor, R.
dc.contributor.authorRobinson, J.
dc.contributor.authorRoberts, C.
dc.date.issued2007
dc.descriptionCopyright © 2007 by The Endocrine Society
dc.description.abstractIn early pregnancy, the concentrations of IGFs increase in maternal blood. Treatment of pregnant guinea pigs with IGFs in early to midpregnancy enhances placental glucose transport and fetal growth and viability near term. In the current study, we determined whether exogenous IGFs altered placental gene expression, transport, and nutrient partitioning during treatment, which may then persist. Guinea pigs were infused with IGF-I, IGF-II (both 1 mg/kg x d) or vehicle sc from d 20-35 of pregnancy and killed on d 35 (term is 70 d) after administration of [(3)H]methyl-D-glucose (MG) and [(14)C]amino-isobutyric acid (AIB). IGF-I increased placental and fetal weights (+15 and +17%, respectively) and MG and AIB uptake by the placenta (+42 and +68%, respectively) and fetus (+59 and +90%, respectively). IGF-I increased placental mRNA expression of the amino acid transporter gene Slc38a2 (+780%) and reduced that of Igf2 (-51%), without altering the glucose transporter Slc2a1 or Vegf and Igf1 genes. There were modest effects of IGF-I treatment on MG and AIB uptake by individual maternal tissues and no effect on plasma glucose, total amino acids, free fatty acids, triglycerides, and cholesterol concentrations. IGF-II treatment of the mother did not alter any maternal, fetal or placental parameter. In conclusion, exogenous IGF-I, but not IGF-II, in early pregnancy increases placental transport of MG and AIB, enhancing midgestational fetal nutrient uptake and growth. This suggests that early pregnancy rises in maternal circulating IGF-I play a major role in regulating placental growth and functional development and thus fetal growth throughout gestation.
dc.description.statementofresponsibilityAmanda N. Sferruzzi-Perri, Julie A. Owens, Prue Standen, Robyn L. Taylor, Jeffrey S. Robinson and Claire T. Roberts
dc.identifier.citationEndocrinology, 2007; 148(9):4362-4370
dc.identifier.doi10.1210/en.2007-0411
dc.identifier.issn0013-7227
dc.identifier.issn0013-7227
dc.identifier.orcidOwens, J. [0000-0002-7498-1353]
dc.identifier.orcidRobinson, J. [0000-0002-4515-6039]
dc.identifier.orcidRoberts, C. [0000-0002-9250-2192]
dc.identifier.urihttp://hdl.handle.net/2440/44211
dc.language.isoen
dc.publisherEndocrine Soc
dc.source.urihttps://doi.org/10.1210/en.2007-0411
dc.subjectPlacenta
dc.subjectAnimals
dc.subjectGuinea Pigs
dc.subjectBirth Weight
dc.subjectAminoisobutyric Acids
dc.subjectMethylglucosides
dc.subjectInsulin-Like Growth Factor I
dc.subjectInsulin-Like Growth Factor II
dc.subjectRNA, Messenger
dc.subjectDNA Primers
dc.subjectOrgan Size
dc.subjectGene Expression Regulation
dc.subjectBiological Transport
dc.subjectPregnancy
dc.subjectFemale
dc.titleEarly pregnancy maternal endocrine insulin-like growth factor I programs the placenta for increased functional capacity throughout gestation
dc.typeJournal article
pubs.publication-statusPublished

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