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Surface-initiated hyperbranched polyglycerol as an ultralow-fouling coating on glass, silicon, and porous silicon substrates

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dc.contributor.authorMoore, E.
dc.contributor.authorDelalat, B.
dc.contributor.authorVasani, R.
dc.contributor.authorMcPhee, G.
dc.contributor.authorThissen, H.
dc.contributor.authorVoelcker, N.
dc.date.issued2014
dc.descriptionData source: Supporting Information, http://pubs.acs.org/doi/suppl/10.1021/am503570v
dc.description.abstractAnionic ring-opening polymerization of glycidol was initiated from activated glass, silicon, and porous silicon substrates to yield thin, ultralow-fouling hyperbranched polyglycerol (HPG) graft polymer coatings. Substrates were activated by deprotonation of surface-bound silanol functionalities. HPG polymerization was initiated upon the addition of freshly distilled glycidol to yield films in the nanometer thickness range. X-ray photoelectron spectroscopy, contact angle measurements, and ellipsometry were used to characterize the resulting coatings. The antifouling properties of HPG-coated surfaces were evaluated in terms of protein adsorption and the attachment of mammalian cells. The adsorption of bovine serum albumin and collagen type I was found to be reduced by as much as 97 and 91%, respectively, in comparison to untreated surfaces. Human glioblastoma and mouse fibroblast attachment was reduced by 99 and 98%, respectively. HPG-grafted substrates outperformed polyethylene glycol (PEG) grafted substrates of comparable thickness under the same incubation conditions. Our results demonstrate the effectiveness of antifouling HPG graft polymer coatings on a selected range of substrate materials and open the door for their use in biomedical applications.
dc.identifier.citationACS applied materials & interfaces, 2014; 6(17):15243-15252
dc.identifier.doi10.1021/am503570v
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.urihttps://hdl.handle.net/1959.8/161277
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.rightsCopyright 2014 American Chemical Society
dc.source.urihttps://doi.org/10.1021/am503570v
dc.subjecthyperbranched polyglycerol
dc.subjectsurface grafting
dc.subjectbiofouling
dc.subjectantifouling
dc.subjectlow-fouling
dc.subjectnonfouling
dc.titleSurface-initiated hyperbranched polyglycerol as an ultralow-fouling coating on glass, silicon, and porous silicon substrates
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915910059701831

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