Anti-Müllerian hormone in guiding the selection of a freeze-all versus a fresh embryo transfer strategy: a cohort study

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dc.contributor.authorHu, K.-L.
dc.contributor.authorYang, R.
dc.contributor.authorXu, H.
dc.contributor.authorMol, B.W.
dc.contributor.authorLi, R.
dc.contributor.authorWang, R.
dc.date.issued2022
dc.descriptionPublished online: 23 July 2022
dc.description.abstractPurpose: To explore an interaction effect between serum anti-Müllerian hormone (AMH) levels and the relative treatment effect of a freeze-all versus a fresh embryo transfer strategy on live birth. Methods: This was a retrospective cohort study investigating couples with infertility and eligible for both freeze-all and fresh embryo transfer between 2017 and 2019. Women with an absolute indication for a freeze-all strategy were excluded. Multivariable fractional polynomial interaction analysis within a logistic regression model was used to evaluate whether the treatment effect of a freeze-all versus a fresh transfer strategy varied at different AMH levels. Non-linear interactions were also considered. The primary outcome was the live birth after the first transfer. Results: A total of 13,503 women underwent a fresh embryo transfer and 2247 women underwent a freeze-all strategy. Live birth rates were slightly higher in the freeze-all group compared to those in the fresh embryo transfer group (35% vs 33%). There was a non-linear interaction between baseline serum AMH levels and the relative treatment effect of a freeze-all strategy versus a fresh transfer strategy on live birth (P = 0.0161). The benefit on live birth from a freeze-all embryo transfer strategy was greatest in women with a high serum level (> 7 ng/ml). The interaction remained valid when different imputation methods were used. Conclusion: As serum AMH level increased, there was a nonlinear increase in relative treatment effect of a freeze-only transfer versus a fresh transfer strategy on live birth, and such an effect reaches its maximum in women with high AMH levels.
dc.description.statementofresponsibilityKai, Lun Hu, Rui Yang, Huiyu Xu, Ben W. Mol, Rong Li, Rui Wang
dc.identifier.citationJournal of Assisted Reproduction and Genetics, 2022; 39(10):2325-2333
dc.identifier.doi10.1007/s10815-022-02564-3
dc.identifier.issn1058-0468
dc.identifier.issn1573-7330
dc.identifier.orcidMol, B.W. [0000-0001-6887-0262] [0000-0001-8337-550X]
dc.identifier.orcidWang, R. [0000-0002-6622-8134]
dc.identifier.urihttps://hdl.handle.net/2440/136297
dc.language.isoen
dc.publisherSpringer (part of Springer Nature)
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/2009767
dc.rights© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022
dc.source.urihttps://doi.org/10.1007/s10815-022-02564-3
dc.subjectAnti-Müllerian hormone
dc.subjectLive birth
dc.subjectFresh embryo transfer
dc.subjectFreeze-all embryo transfer
dc.subjectIVF
dc.titleAnti-Müllerian hormone in guiding the selection of a freeze-all versus a fresh embryo transfer strategy: a cohort study
dc.title.alternativeAnti-Mullerian hormone in guiding the selection of a freeze-all versus a fresh embryo transfer strategy: a cohort study
dc.typeJournal article
pubs.publication-statusPublished

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