Molecular regulation of cardiomyocyte maturation /
Files
(Published version)
Date
2023
Authors
Dimasi, Catherine Grace
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
thesis
Citation
Statement of Responsibility
Conference Name
Abstract
Cardiovascular disease (CVD) remains the leading cause of death worldwide. Evidence suggests that cardiovascular disorders in adult life may be derived from insults during fetal development. Chapter 1 is a review discussing cardiomyocyte (CM) maturation. We discuss several factors that contribute to CM maturation, including miRNAs (miRs), glucose and oxygen. Chapters 2 and 3 discuss how fetal growth restriction (FGR) may affect the heart, and we found altered cardiac metabolism and function in FGR fetuses. In Chapter 4, we studied the CM transition period. We found a decline in proliferation and metabolism in late gestation. In Chapter 5, we investigated a potential novel treatment for cardiac repair, miR-558, in a model of myocardial infarction. We found genes involved in proliferation were significantly upregulated in the infarcted area in the miR-558 inhibitor group only.
School/Discipline
University of South Australia. UniSA Clinical and Health Sciences.
UniSA Clinical and Health Sciences
UniSA Clinical and Health Sciences
Dissertation Note
Thesis (PhD(Medical Science))--University of South Australia, 2023.
Provenance
Copyright 2023 Catherine Grace Dimasi.
Description
1 ethesis (xxi, 236 pages) :
colour illustrations, charts, photographs.
Includes bibliographical references
colour illustrations, charts, photographs.
Includes bibliographical references
Access Status
506 0#$fstar $2Unrestricted online access