Variability of serum markers of erythropoiesis during 6 days of racing in highly trained cyclists
Date
2014
Authors
Voss, S.C.
Alsayrafi, M.
Bourdon, P.C.
Klodt, F.
Nonis, D.
Hopkins, W.G.
Schumacher, Y.O.
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Journal article
Citation
International Journal of Sports Medicine, 2014; 35(2):89-94
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Abstract
The athlete biological passport for the fight against doping is currently based on longitudinal monitoring for abnormal changes in cellular blood parameters. Serum parameters related to altered erythropoiesis could be considered for inclusion in the passport. The aim of this study was to quantify the changes in such parameters in athletes during a period of intense exercise.12 highly trained cyclists tapered for 3 days before 6 days of simulated intense stage racing.Morning and afternoon blood samples were taken on most days and analysed for total protein,albumin, soluble transferrin receptor andferritin concentrations. Plasma volume wasdetermined via total haemoglobin mass measuredby carbon-monoxide rebreathing.
Percent changes in means from baseline and percent standard errors of measurement (analytical error plus intra-athlete variation) on each measurement occasion were estimated with mixed linear modelling of log-transformed measures.Means of all variables changed substantially in the days following the onset of racing, ranging from − 13 % (haemoglobin concentration) to + 27 %(ferritin). After the second day, errors of measurement were generally twice those at baseline.Plasma variables were affected by heavy exercise,either because of changes in plasma volume(total protein, albumin, haemoglobin), acute phase/inflammatory reactions (ferritin) or both(soluble transferrin receptor). These effects need to be taken into consideration when integrating a plasma parameter into the biological passportmodel for athletes.
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Link to a related website: https://openrepository.aut.ac.nz/bitstream/10292/5737/2/hopkins.pdf, Open Access via Unpaywall
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Copyright 2014 Georg Thieme Verlag