A nutrigenomic study of folate/methionine status and oxidative stress in autistic disorder /
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(Published version)
Date
2013
Authors
Main, Penelope,
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thesis
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Abstract
Autism spectrum disorders are a heterogeneous group of neurodevelopmental conditions characterized by impairments in reciprocal social interactions, communication and stereotyped behaviours. While the exact cause of autism is unknown, it is widely accepted to have a strong genetic component together with an environmental trigger. The aim of this thesis was to investigate the role of genome stability in the aetiology of autistic disorder.Recent studies have reported differences in folate transport, methionine metabolism and glutathione redox ratio in children with autism. Folate is required for deoxyribonucleic acid(DNA) synthesis, whereas methionine metabolism is important for gene expression and glutathione is an antioxidant protein that plays a key role in detoxification. In this thesis two systematic reviews were completed to explore the association of these metabolic pathways with autistic disorder (1, 2). The first systematic review showed that evidence for the involvement of folate/methionine metabolism in autistic disorder was inconclusive. The second systematic review and meta-analysis of the potential antioxidant and detoxification properties of glutathione in autism spectrum disorders concluded that the evidence was sufficiently strong, particularly for glutathione redox ratio, to warrant further investigation.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (PhD)--University of South Australia, 2013.
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Copyright 2013 Penelope Main
Description
1 ethesis (323 pages) :
illustrations.
Includes bibliographical references (pages 197-245)
illustrations.
Includes bibliographical references (pages 197-245)
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