Caspase-2 and the oxidative stress response
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Date
2015
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Shalini, S.
Kumar, S.
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Journal article
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Molecular & Cellular Oncology, 2015; 2(4):e1004956-1-e1004956-3
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Sonia Shalini and Sharad Kumar
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Abstract
Caspase-2, one of the earliest discovered caspases, has emerged as a multifunctional enzyme with roles that are not limited to cell death. It acts as a tumor suppressor, prevents genetic instability, and protects against aging by playing a crucial role in sensing alterations in cellular redox status and activating the antioxidant defense system. These apparent non-apoptotic functions, only discovered recently, emphasize the importance of this often-neglected protease.
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© Sonia Shalini and Sharad Kumar This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.