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Surgical incision induces anxiety-like behavior and amygdala sensitization: Effects of morphine and gabapentin

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dc.contributor.authorLi, C.Q.
dc.contributor.authorZhang, J.W.
dc.contributor.authorDai, R.P.
dc.contributor.authorWang, J.
dc.contributor.authorLuo, X.G.
dc.contributor.authorZhou, X.F.
dc.date.issued2010
dc.description.abstractThe role of affective dimension in the postoperative pain is still poorly understood. The present study investigated the development of anxiety-like behavior and amygdala sensitization in incisional pain. Using hind-paw incision model in rats, we showed that surgical incision induced the anxiety-like behavior as determined by elevated plus-maze and open-field tests. Intraperitoneal (IP) morphine administration reversed mechanical allodynia and anxiety-like behavior in a dose-dependent manner. Gabapentin also partially reduced incision-evoked mechanical allodynia and anxiety-like behavior in a dose-dependent manner. After incision, the expression of phosphorylated cAMP response elements (CRE-) binding protein (p-CREB) was transiently upregulated in the central and basolateral nuclei in the bilateral amygdala. The upregulation of p-CREB was inhibited by morphine and gabapentin. The present study suggested that surgical incision could induce anxiety and amygdala sensitization that can be inhibited by morphine and gabapentin. Thus treatment of surgery-induced affective disturbances by morphine and gabapentin may be a potential important adjunct therapy in the postoperative pain management.
dc.identifier.citationPain Research and Treatment, 2010; 2010(705874):1-9
dc.identifier.doi10.1155/2010/705874
dc.identifier.issn2090-1542
dc.identifier.issn2090-1550
dc.identifier.orcidZhou, X.F. [0000-0002-8687-0175]
dc.identifier.urihttps://hdl.handle.net/1959.8/156349
dc.language.isoen
dc.publisherHindawi Publishing Corporation
dc.rightsCopyright 2010 Chang-Qi Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.source.urihttps://doi.org/10.1155/2010/705874
dc.titleSurgical incision induces anxiety-like behavior and amygdala sensitization: Effects of morphine and gabapentin
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915910217001831

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