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Cytochromes P450: Decision-making tools for personalized therapeutics

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dc.contributor.authorMurray, M.
dc.contributor.authorPetrovic, N.
dc.date.issued2006
dc.description.abstractThe responses of patients to standard drug regimens vary widely, with dose responses ranging from subtherapeutic to toxic. The primary goal of individualized medicine is the optimization of drug therapy, which involves the selection of appropriate drugs, dosages and drug combinations, and the minimization of toxic side effects. The cytochrome P450 (CYP) enzymes mediate the oxidative biotransformation of most drugs, and are important determinants of the duration of drug action. CYPs exhibit a large number of allelic variants that may encode defective enzymes or no enzyme at all. The expression and function of these enzymes are also influenced ( induced or inhibited) by non-genetic factors. Patients with diminished CYP capacity may require lower than normal doses of certain drugs, whereas those with an increased metabolic capacity may need higher than normal doses in order to achieve full efficacy. This review focuses on the recent developments in the field of CYP pharmacogenetics that include characterization of the substrate- and inhibitor-specificity of CYP variant enzymes, and the increasing evidence that polygenic factors influence the design of personalized drug regimens.
dc.identifier.citationCurrent Opinion in Molecular Therapeutics, 2006
dc.identifier.issn1464-8431
dc.identifier.urihttps://hdl.handle.net/1959.8/121877
dc.language.isoen
dc.publisherThomson Reuters
dc.rightsCopyright 2006 Thomson Reuters
dc.subjectCYP alleles
dc.subjectCYP pharmacogenetics
dc.subjectdrug interactions
dc.subjectgenotype-phenotype association
dc.subjectindividualized medicine
dc.subjectinter-individual variation
dc.titleCytochromes P450: Decision-making tools for personalized therapeutics
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915911567001831

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