Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.
Date
2008
Authors
McDevitt, C.
Shintre, C.
Grossmann, G.
Pollock, N.
Prince, S.
Callaghan, R.
Ford, R.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
FEBS Letters, 2008; 582(19):2950-2956
Statement of Responsibility
Christopher A. McDevitt, Chitra A. Shintre, J. Günter Grossmann, Naomi L. Pollock, Stephen M. Prince, Richard Callaghan, Robert C. Ford
Conference Name
Abstract
P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.