Drosophila simulans: a species with improved resolution in evolve and resequence studies

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dc.contributor.authorBarghi, N.
dc.contributor.authorTobler, R.
dc.contributor.authorNolte, V.
dc.contributor.authorSchlötterer, C.
dc.date.issued2017
dc.description.abstractThe combination of experimental evolution with high-throughput sequencing of pooled individuals-i.e., evolve and resequence (E&R)-is a powerful approach to study adaptation from standing genetic variation under controlled, replicated conditions. Nevertheless, E&R studies in Drosophila melanogaster have frequently resulted in inordinate numbers of candidate SNPs, particularly for complex traits. Here, we contrast the genomic signature of adaptation following ∼60 generations in a novel hot environment for D. melanogaster and D. simulans For D. simulans, the regions carrying putatively selected loci were far more distinct, and thus harbored fewer false positives, than those in D. melanogaster We propose that species without segregating inversions and higher recombination rates, such as D. simulans, are better suited for E&R studies that aim to characterize the genetic variants underlying the adaptive response.
dc.description.statementofresponsibilityNeda Barghi, Raymond Tobler, Viola Nolte and Christian Schlötterer
dc.identifier.citationG3: Genes, Genomes, Genetics, 2017; 7(7):2337-2343
dc.identifier.doi10.1534/g3.117.043349
dc.identifier.issn2160-1836
dc.identifier.issn2160-1836
dc.identifier.orcidTobler, R. [0000-0002-4603-1473]
dc.identifier.urihttp://hdl.handle.net/2440/107175
dc.language.isoen
dc.publisherGenetics Society of America
dc.rightsCopyright © 2017 Barghi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.source.urihttps://doi.org/10.1534/g3.117.043349
dc.subjectExperimental evolution; evolve and resequence; Drosophila simulans; Drosophila melanogaster; chromosomal inversions
dc.titleDrosophila simulans: a species with improved resolution in evolve and resequence studies
dc.typeJournal article
pubs.publication-statusPublished

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