The gut microbiome regulates host glucose homeostasis via peripheral serotonin

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dc.contributor.authorMartin, A.M.
dc.contributor.authorYabut, J.M.
dc.contributor.authorChoo, J.M.
dc.contributor.authorPage, A.J.
dc.contributor.authorSun, E.W.
dc.contributor.authorJessup, C.F.
dc.contributor.authorWesselingh, S.L.
dc.contributor.authorKhan, W.I.
dc.contributor.authorRogers, G.B.
dc.contributor.authorSteinberg, G.R.
dc.contributor.authorKeating, D.J.
dc.date.issued2019
dc.description.abstractThe gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unknown. The gut microbiome is also a potent mediator of gut-derived serotonin synthesis, and this peripheral source of serotonin is itself a regulator of glucose homeostasis. Here, we determined whether the gut microbiome influences glucose homeostasis through effects on gut-derived serotonin. Using both pharmacological inhibition and genetic deletion of gut-derived serotonin synthesis, we find that the improvements in host glucose handling caused by antibiotic-induced changes in microbiota composition are dependent on the synthesis of peripheral serotonin.
dc.description.statementofresponsibilityAlyce M. Martin, Julian M. Yabut, Jocelyn M. Choo, Amanda J. Page, Emily W. Sun, Claire F. Jessup, Steve L. Wesselingh, Waliul I. Khan, Geraint B. Rogers, Gregory R. Steinbergb, and Damien J. Keating
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2019; 116(40):19802-19804
dc.identifier.doi10.1073/pnas.1909311116
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.orcidPage, A.J. [0000-0002-7086-5865]
dc.identifier.orcidJessup, C.F. [0000-0003-1184-6653]
dc.identifier.urihttp://hdl.handle.net/2440/122504
dc.language.isoen
dc.publisherPNAS
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1088737
dc.rightsCopyright © 2019 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial- NoDerivatives License 4.0 (CC BY-NC-ND).
dc.source.urihttps://doi.org/10.1073/pnas.1909311116
dc.subjectglucose homeostasis
dc.subjectmicrobe−host interactions
dc.subjectmicrobiome
dc.subjectserotonin
dc.titleThe gut microbiome regulates host glucose homeostasis via peripheral serotonin
dc.typeJournal article
pubs.publication-statusPublished

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