Power spectral analysis of heart rate variability in children and adolescents with IDDM

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dc.contributor.authorWawryk, A.
dc.contributor.authorBates, D.
dc.contributor.authorCouper, J.
dc.date.issued1997
dc.description.abstract<h4>Objective</h4>To investigate power spectral analysis (PSA) of heart rate variability (HRV) in children and adolescents with IDDM, its relationship with other measures of HRV and standard cardiovascular responses, and factors associated with reduced HVR.<h4>Research design and methods</h4>A total of 130 subjects with IDDM aged 12.8 +/- 3.2 years and 108 healthy control subjects were studied. Power spectra were analyzed from supine electrocardiograph (ECG) recordings by processing into consecutive R-R intervals and analysis using fast Fourier transformation. Standard cardiovascular responses to deep breathing and standing were performed.<h4>Results</h4>IDDM subjects had a reduction in total power including both low-frequency (0.05-0.14 Hz; P = 0.0001) and high-frequency (0.14-0.40 Hz; P = 0.0002) components. These changes were seen from diagnosis. Other measures of HRV, coefficient of variation (CV) and standard deviation (SD) of mean resting heart rate, were also significantly lower in IDDM. All 20 (15%) of the 130 IDDM subjects with total power less than the 5th percentile in control subjects also had reduced HRV when measured by CV of heart rate. There was an independent relationship between age and the high-frequency component in IDDM subjects and control subjects. Total power correlated with mean heart rate (r = -0.56; P < 0.0001), CV of heart rate (r = 0.90; P < 0.00001), SD of heart rate (r = 0.91; P < 0.00001), heart rate response to deep breathing (r = 0.45; P < 0.0001), and duration in IDDM subjects. There was no correlation with short-term or long-term metabolic control. Retesting of 27 subjects showed a variability in total power and its components comparable to other measures of HRV and standard heart rate responses.<h4>Conclusions</h4>Changes in HRV are a sensitive and reproducible measure of early autonomic dysfunction in childhood. In this age-group, PSA appears no more sensitive a measure of reduced HRV than other closely correlated measures of HRV.
dc.description.statementofresponsibilityAndrew M Wawryk, David J Bates, and Jennifer J Couper
dc.identifier.citationDiabetes Care, 1997; 20(9):1416-1421
dc.identifier.doi10.2337/diacare.20.9.1416
dc.identifier.issn0149-5992
dc.identifier.issn1935-5548
dc.identifier.orcidBates, D. [0000-0003-3849-6374]
dc.identifier.orcidCouper, J. [0000-0003-4448-8629]
dc.identifier.urihttp://hdl.handle.net/2440/7185
dc.language.isoen
dc.publisherAMER DIABETES ASSOC
dc.source.urihttps://doi.org/10.2337/diacare.20.9.1416
dc.subjectSympathetic Nervous System
dc.subjectHumans
dc.subjectDiabetes Mellitus, Type 1
dc.subjectElectrocardiography
dc.subjectSpectroscopy, Fourier Transform Infrared
dc.subjectAge Factors
dc.subjectHeart Rate
dc.subjectRespiration
dc.subjectPosture
dc.subjectTime Factors
dc.subjectReference Values
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectMale
dc.subjectCardiovascular Physiological Phenomena
dc.titlePower spectral analysis of heart rate variability in children and adolescents with IDDM
dc.typeJournal article
pubs.publication-statusPublished

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