Molecular regulation of cardiac regeneration post-myocardial infarction /
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(Published version)
Date
2019
Authors
Lock, Mitchell Clay
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Type:
thesis
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Abstract
Cardiovascular disease is the leading cause of morbidity and mortality worldwide. The fetal heart has the unique ability to regenerate and repair after myocardial infarction (MI) through proliferation of cardiomyocytes. This response is blocked in the adolescent heart. Within this thesis we investigated three possible sources for the different response to damage between fetal and postnatal life (Physiological, Gene, and miRNA response) using a sheep model of MI. We used array experiments to probe thousands of genes and miRNAs to identify possible therapeutic targets of myocardial repair. The results indicate that the fetal heart has a strong resistance to damage, alongside unique modulation of miRNAs involved in proliferation and inflammation. Targeting the uniquely expressed genes and miRNAs identified in this thesis may lead to the development of beneficial treatments for heart attack.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (PhD(Medical Science))--University of South Australia, 2019.
Provenance
Copyright 2019 Mitchell Clay Lock.
Description
1 ethesis (xxxvi, 267 pages) :
illustrations (some colour), charts (some colour)
Includes bibliographical references.
illustrations (some colour), charts (some colour)
Includes bibliographical references.
Access Status
506 0#$fstar $2Unrestricted online access