Discovery of lost diversity of paternal horse lineages using ancient DNA

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dc.contributor.authorLippold, S.
dc.contributor.authorKnapp, M.
dc.contributor.authorKuznetsova, T.
dc.contributor.authorLeonard, J.
dc.contributor.authorBenecke, N.
dc.contributor.authorLudwig, A.
dc.contributor.authorRasmussen, M.
dc.contributor.authorCooper, A.
dc.contributor.authorWeinstock, J.
dc.contributor.authorWillerslev, E.
dc.contributor.authorShapiro, B.
dc.contributor.authorHofreiter, M.
dc.date.issued2011
dc.description.abstractModern domestic horses display abundant genetic diversity within female-inherited mitochondrial DNA, but practically no sequence diversity on the male-inherited Y chromosome. Several hypotheses have been proposed to explain this discrepancy, but can only be tested through knowledge of the diversity in both the ancestral (pre-domestication) maternal and paternal lineages. As wild horses are practically extinct, ancient DNA studies offer the only means to assess this ancestral diversity. Here we show considerable ancestral diversity in ancient male horses by sequencing 4 kb of Y chromosomal DNA from eight ancient wild horses and one 2,800-year-old domesticated horse. Both ancient and modern domestic horses form a separate branch from the ancient wild horses, with the Przewalski horse at its base. Our methodology establishes the feasibility of re-sequencing long ancient nuclear DNA fragments and demonstrates the power of ancient Y chromosome DNA sequence data to provide insights into the evolutionary history of populations.
dc.description.statementofresponsibilitySebastian Lippold, Michael Knapp, Tatyana Kuznetsova, Jennifer A. Leonard, Norbert Benecke, Arne Ludwig, Morten Rasmussen, Alan Cooper, Jaco Weinstock, Eske Willerslev, Beth Shapiro and Michael Hofreiter
dc.identifier.citationNature Communications, 2011; 2(1):1-6
dc.identifier.doi10.1038/ncomms1447
dc.identifier.issn2041-1723
dc.identifier.issn2041-1723
dc.identifier.orcidCooper, A. [0000-0002-7738-7851]
dc.identifier.urihttp://hdl.handle.net/2440/67367
dc.language.isoen
dc.publisherNature Publishing Group
dc.rights© 2011 Macmillan Publishers Limited. All rights reserved.
dc.source.urihttps://doi.org/10.1038/ncomms1447
dc.subjectY Chromosome
dc.subjectAnimals
dc.subjectHorses
dc.subjectDNA, Mitochondrial
dc.subjectEvolution, Molecular
dc.subjectPhylogeny
dc.subjectMolecular Sequence Data
dc.subjectFemale
dc.subjectMale
dc.subjectGenetic Variation
dc.titleDiscovery of lost diversity of paternal horse lineages using ancient DNA
dc.typeJournal article
pubs.publication-statusPublished

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