TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma

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dc.contributor.authorRae, F.
dc.contributor.authorHooper, J.
dc.contributor.authorEyre, H.
dc.contributor.authorSutherland, G.
dc.contributor.authorNicol, D.
dc.contributor.authorClements, J.
dc.date.issued2001
dc.description.abstractUsing differential display PCR, we identified a novel gene upregulated in renal cell carcinoma. Characterization of the full-length cDNA and gene revealed that the encoded protein is a human homologue of the Drosophila melanogaster Tweety protein, and so we have termed the novel protein TTYH2. The orthologous mouse cDNA was also identified and the predicted mouse protein is 81% identical to the human protein. The encoded human TTYH2 protein is 534 amino acids and, like the other members of the tweety-related protein family, is a putative cell surface protein with five transmembrane regions. TTYH2 is located at 17q24; it is expressed most highly in brain and testis and at lower levels in heart, ovary, spleen, and peripheral blood leukocytes. Expression of this gene is upregulated in 13 of 16 (81%) renal cell carcinoma samples examined. In addition to a putative role in brain and testis, the over-expression of TTYH2 in renal cell carcinoma suggests that it may have an important role in kidney tumorigenesis.
dc.identifier.citationGenomics, 2001; 77(3):200-207
dc.identifier.doi10.1006/geno.2001.6629
dc.identifier.issn0888-7543
dc.identifier.issn1089-8646
dc.identifier.urihttp://hdl.handle.net/2440/7274
dc.language.isoen
dc.publisherAcademic Press Inc
dc.source.urihttps://doi.org/10.1006/geno.2001.6629
dc.subjectTestis
dc.subjectBrain
dc.subjectChromosomes, Human, Pair 17
dc.subjectAnimals
dc.subjectHumans
dc.subjectMice
dc.subjectDrosophila melanogaster
dc.subjectCarcinoma, Renal Cell
dc.subjectKidney Neoplasms
dc.subjectMembrane Proteins
dc.subjectNeoplasm Proteins
dc.subjectDNA, Complementary
dc.subjectIn Situ Hybridization, Fluorescence
dc.subjectChromosome Mapping
dc.subjectGene Expression Profiling
dc.subjectPolymerase Chain Reaction
dc.subjectSequence Alignment
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectUp-Regulation
dc.subjectAmino Acid Sequence
dc.subjectMolecular Sequence Data
dc.subjectFemale
dc.subjectMale
dc.titleTTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma
dc.typeJournal article
pubs.publication-statusPublished

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