Contractile and Ca2+-handling properties of the right ventricular papillary muscle in the late-gestation sheep fetus
Date
2006
Authors
Spencer, T.N.
Botting, K.J.
Morrison, J.L.
Posterino, G.S.
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Journal of applied physiology, 2006; 101(3):728-733
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Abstract
The force-generating capacity of cardiomyocytes rapidly changes during gestation and early postnatal life coinciding with a transition in cardiomyocyte nucleation in both mice and rats. Changes in nucleation, in turn, appear to coincide with important changes in the excitation-contraction coupling architecture. However, it is not clear whether similar changes are observed in other mammals in which this transition occurs prenatally, such as sheep. Using small (70-300 mu M diameter) chemically skinned cardiomyocyte bundles from the right ventricular papillary muscle of sheep fetuses at 126-132 and 137-140 days (d) gestational age (GA), we aimed to examine whether changes in cardiomyocyte nucleation during late gestation coincided with developmental changes in excitation-contraction coupling parameters ( e. g., Ca2+ uptake, Ca2+ release, and force development).
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Copyright 2006 the American Physiological Society