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Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol

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dc.contributor.authorScopacasa, F.
dc.contributor.authorWishart, J.
dc.contributor.authorHorowitz, M.
dc.contributor.authorMorris, H.
dc.contributor.authorNeed, A.
dc.date.issued2004
dc.descriptionCopyright © 2004 Nature Publishing Group
dc.description.abstractOBJECTIVE: To obtain information on the causes of age-related bone loss in men and the concomitant decline in calcium absorption. DESIGN: Cross-sectional study. SETTING: Adelaide, South Australia, Australia. SUBJECTS: A total of 95 healthy, Caucasian men (age range 27-87 y). RESULTS: Calcium absorption declined with age (r=-0.46, P<0.0001), as did 24-h urine calcium, phosphate and creatinine (r>-0.21, P<0.05 for all); serum calcitriol and 25 hydroxyvitamin D did not change with age. Calcium absorption was related to serum calcitriol (r=0.20, P=0.05). An inverse relation between the residual deviations in calcium absorption, after allowing for its dependence on calcitriol, and age (F=5.4, P<0.005) was observed. The 24-h urinary calcium, phosphate and creatinine were all related to calcium absorption (r>0.41, P<0.0001). Forearm bone density fell with age (r=-0.45, P<0.0001) but was not related to calcium absorption, or markers of bone turnover. CONCLUSIONS: In healthy Caucasian males (i) calcium absorption falls, but serum calcitriol does not change with age, (ii) the relation between calcium absorption and serum calcitriol changes with age, indicative of an intestinal resistance to calcitriol and (iii) calcium absorption is a significant determinant of 24-h urinary calcium excretion.
dc.description.statementofresponsibilityF Scopacasa, JM Wishart, M Horowitz, HA Morris and AG Need
dc.identifier.citationEuropean Journal of Clinical Nutrition, 2004; 58(2):264-269
dc.identifier.doi10.1038/sj.ejcn.1601777
dc.identifier.issn0954-3007
dc.identifier.issn1476-5640
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidMorris, H. [0000-0002-2745-3750]
dc.identifier.urihttp://hdl.handle.net/2440/9437
dc.language.isoen
dc.publisherNature Publishing Group
dc.source.urihttps://doi.org/10.1038/sj.ejcn.1601777
dc.subjectcalcium absorption
dc.subjectcalcitriol
dc.subjectnormal men
dc.subjectbone density
dc.titleRelation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to calcitriol
dc.typeJournal article
pubs.publication-statusPublished

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