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Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers

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dc.contributor.authorWunnapuk, K.
dc.contributor.authorGobe, G.
dc.contributor.authorEndre, Z.
dc.contributor.authorPeake, P.
dc.contributor.authorGrice, J.E.
dc.contributor.authorRoberts, M.S.
dc.contributor.authorBuckley, N.A.
dc.contributor.authorLiu, X.
dc.date.issued2014
dc.descriptionData source: Supplementary data, https://doi.org/10.1016/j.toxlet.2013.12.009
dc.description.abstractAccidental or intentional ingestion of glyphosate surfactant-based herbicides, like Roundup®, leads tonephrotoxicity as well as death. In this study, a panel of kidney injury biomarkers was evaluated in termsof suitability to detect acute kidney injury and dysfunction. The Roundup®intoxication model involvedoral administration of glyphosate to rats at dose levels of 250, 500, 1200 and 2500 mg/kg. Urinary andplasma biomarker patterns were investigated at 8, 24 and 48 h after dosing. Biomarkers were quantifiedby absolute concentration; by normalising to urine creatinine; and by calculating the excretion rate. Thediagnostic performances of each method in predicting of acute kidney injury were compared. By ReceiverOperating Characteristic (ROC) analysis of the selected biomarkers, only urinary kidney injury molecule-1(KIM-1) best predicted histological changes at 8 h (best cut-off point > 0.00029 g/ml). Plasma creatinineperformed better than other biomarkers at 24 h (best cut-off point > 0.21 mg/dl). Urinary KIM-1 was thebest early biomarker of kidney injury in this glyphosate-induced nephrotoxicity model.
dc.identifier.citationToxicology Letters, 2014; 225(1):192-200
dc.identifier.doi10.1016/j.toxlet.2013.12.009
dc.identifier.issn0378-4274
dc.identifier.issn1879-3169
dc.identifier.urihttps://hdl.handle.net/1959.8/159694
dc.language.isoen
dc.publisherElsevier Ireland
dc.relation.fundingNHMRC 1011772
dc.relation.fundingChiang Mai University Faculty of Development Fund
dc.relation.fundingUniversity of Queensland
dc.rightsCopyright 2013 Elsevier Ireland Access Condition Notes: Accepted manuscript only available on Open Access
dc.source.urihttps://doi.org/10.1016/j.toxlet.2013.12.009
dc.subjectglyphosate
dc.subjectacute kidney injury
dc.subjectkidney injury molecule-1
dc.subjectcystatin-C
dc.subjectcreatinine
dc.subjectroundup
dc.titleUse of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers
dc.typeJournal article
pubs.publication-statusPublished
ror.fileinfo12160347510001831 13196939910001831 9915910035301831_12160347510001831_13160347500001831_CS
ror.mmsid9915910035301831

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