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Effects of physiological hyperglycemia on duodenal motility and flow events, glucose absorption, and incretin secretion in healthy humans

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dc.contributor.authorKuo, P.
dc.contributor.authorWishart, J.
dc.contributor.authorBellon, M.
dc.contributor.authorSmout, A.
dc.contributor.authorHolloway, R.
dc.contributor.authorFraser, R.
dc.contributor.authorHorowitz, M.
dc.contributor.authorJones, K.
dc.contributor.authorRayner, C.
dc.date.issued2010
dc.description.abstractContext: Acute hyperglycemia slows gastric emptying, but its effects on small intestinal motor activity and glucose absorption are unknown. In type 2 diabetes, the postprandial secretion of glucose-dependent insulinotropic polypeptide (GIP) is preserved, but that of glucagon-like peptide-1 (GLP-1) is possibly reduced; whether the latter is secondary to hyperglycemia or diabetes per se is unknown. Aim: The aim was to investigate the effects of acute hyperglycemia on duodenal motility and flow events, glucose absorption, and incretin hormone secretion. Methods: Nine healthy volunteers were studied on two occasions. A combined manometry/impedance catheter was positioned in the duodenum. Blood glucose was clamped at either 9 mmol/ liter (hyperglycemia) or 5 mmol/liter (euglycemia) throughout the study. Manometry and impedance recordings continued between T__10 min and T _ 180 min. Between T _ 0 and 60 min, an intraduodenal glucose infusion was given (_3 kcal/min), together with 14C-labeled 3-O-methylglucose (3-OMG) to evaluate glucose absorption. Results: Hyperglycemia had no effect on duodenal pressure waves or flow events during the 60 min of intraduodenal glucose infusion, when compared to euglycemia. During hyperglycemia, there was an increase in plasma GIP (P _ 0.05) and 14C-3-OMG (P _ 0.05) but no effect on GLP-1 concentrations in response to the intraduodenal infusion, compared to euglycemia. Conclusion: Acute hyperglycemia in the physiological range has no effect on duodenal pressure waves and flow events but is associated with increased GIP secretion and rate of glucose absorption in response to intraduodenal glucose.
dc.description.statementofresponsibilityPaul Kuo, Judith M. Wishart, Max Bellon, André J. Smout, Richard H. Holloway, Robert J. L. Fraser, Michael Horowitz, Karen L. Jones and Christopher K. Rayner
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism, 2010; 95(8):3893-3900
dc.identifier.doi10.1210/jc.2009-2514
dc.identifier.issn0021-972X
dc.identifier.issn0021-972X
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]
dc.identifier.urihttp://hdl.handle.net/2440/61722
dc.language.isoen
dc.publisherEndocrine Society
dc.rightsCopyright © 2010 by The Endocrine Society
dc.source.urihttps://doi.org/10.1210/jc.2009-2514
dc.subjectDuodenum
dc.subjectHumans
dc.subjectHyperglycemia
dc.subjectGastric Inhibitory Polypeptide
dc.subjectGlucagon
dc.subjectInsulin
dc.subjectGlucose
dc.subjectBlood Glucose
dc.subjectAnalysis of Variance
dc.subjectArea Under Curve
dc.subjectSingle-Blind Method
dc.subjectManometry
dc.subjectElectric Impedance
dc.subjectGastrointestinal Motility
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.subjectGlucagon-Like Peptide 1
dc.subjectIncretins
dc.titleEffects of physiological hyperglycemia on duodenal motility and flow events, glucose absorption, and incretin secretion in healthy humans
dc.typeJournal article
pubs.publication-statusPublished

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