Proteomics investigation of human platelets in healthy donors and cystic fibrosis patients by shotgun nUPLC-MS E and 2DE: a comparative study
Date
2011
Authors
Pieroni, L.
Finamore, F.
Ronci, M.
Mattoscio, D.
Marzano, V.
Mortera, S.L.
Quattrucci, S.
Federici, G.
Romano, M.
Urbani, A.
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Journal article
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Molecular Biosystems, 2011; 7(3):630-639
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Abstract
Platelets are of pathophysiological relevance in haemostasis, wound repair, inflammation and cardiovascular disease. We have shown that human platelets express a biologically active Cystic Fibrosis Transmembrane Conductance Regulator, which is dysfunctional in Cystic Fibrosis (CF) patients, and regulate platelet responses related to inflammation and its resolution. In order to further elucidate platelet involvement in CF inflammation, we pursued a comparative proteomicanalysis of cells from healthy donors and CF patients, in association with a non-supervised comparative analysis of the Gene Ontology. Our results, showing changes in the integrin signalling in CF, support a pro-inflammatory profile of CF platelets.
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Copyright 2011 Royal Society of Chemistry