Modeling the effect of daughter migration on dosimetry estimates for unlabeled actinium-225
Date
2024
Authors
Tronchin, S.
Forster, J.
Hickson, K.
Bezak, E.
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Journal article
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Medical Physics, 2024; 51(7):5032-5044
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Abstract
Background: Actinium-225 (²²⁵Ac) is an alpha emitting radionuclide which has demonstrated promising results in Targeted Alpha Therapy (TAT). A concern with ²²⁵Ac is that the decay energy can break the bond to the targeting vehicle, resulting in the release of free alpha-emitting daughter radionuclides in the body.
Purpose: The aim of this work is to develop a compartment model to describe the movement of unlabeled ²²⁵Ac in a human where the daughter isotopes of ²²⁵Ac have unique biokinetics.
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Copyright 2024 the Authors. This is an open access article under the terms of the Creative Commons Attribution License. (http://creativecommons.org/licenses/by/4.0/)