Co-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye development

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dc.contributor.authorKanai-Azuma, Masamien
dc.contributor.authorMattick, John S.en
dc.contributor.authorKaibuchi, Kozoen
dc.contributor.authorWood, Stephen Andrewen
dc.contributor.organisationCentre for the Molecular Genetics of Developmenten
dc.contributor.schoolSchool of Molecular and Biomedical Scienceen
dc.date.issued2000en
dc.description.abstractThe Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF-6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras target AF-6 is a substrate of the fam deubiquitinating enzyme. J. Cell Biol. 142, 1053–1062). We report here that the expression of the FAM and AF-6 proteins overlaps extensively in the mouse eye from embryogenesis to maturity, especially in the non-neural epithelia including the retinal pigment epithelium, subcapsular epithelium of the lens and corneal epithelium. Expression is not limited to the epithelia however, as FAM and AF-6 also co-localize during lens fibre development as well as in sub-populations of the neural retina.en
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/506090/description#descriptionen
dc.identifier.citationMechanisms of Development, 2000; 91(1-2):383-386en
dc.identifier.doi10.1016/S0925-4773(99)00294-4en
dc.identifier.issn0925-4773en
dc.identifier.urihttp://hdl.handle.net/2440/28008
dc.language.isoenen
dc.publisherElsevier Scienceen
dc.subjectFAM; De-ubiquitinating enzyme; AF-6; Canoe; Ras-binding protein; Retinal pigment epithelium; Lens epithelium; Corneal epitheliumen
dc.titleCo-localization of FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in mouse eye developmenten
dc.typeJournal articleen

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