Current studentsExisting staffContact us
 

Vitamin D and chronic widespread pain in a white middle-aged British population: Evidence from a cross-sectional population survey

Simple item page
dc.contributor.authorAtherton, K.
dc.contributor.authorBerry, D.J.
dc.contributor.authorParsons, T.
dc.contributor.authorMacfarlane, G.J.
dc.contributor.authorPower, C.
dc.contributor.authorHyppönen, E.
dc.date.issued2009
dc.descriptionData source: Additional table, https://doi.org/10.1136/ard.2008.090456
dc.description.abstractBackground: Identified aetiological factors for chronic widespread pain (CWP) are largely related to emotional and behavioural factors, but current management leads to modest improvement in symptoms. Vitamin D deficiency has been suggested as a new modifiable risk factor for CWP. Objective: To examine the association between vitamin D status (measured by 25-hydroxyvitamin D (25(OH)D)) and CWP in a nationwide population sample of white British adults, accounting for potential mediating and confounding lifestyle factors. Methods: 9377 participants born 1 week in March 1958, in England, Scotland or Wales and completing a biomedical assessment at age 45; 6824 eligible participants had data on 25(OH)D and completed pain manikins. Results: Prevalence of CWP varied by 25(OH)D concentration in women but not in men, with the lowest prevalence observed for women with 75–99 nmol/l (14.4% for <25 nmol/l, 14.8% for 25–49 nmol/l, 11.6% for 50–74 nmo/l, 8.2% for 75–99 nmol/l and 9.8% for participants with ⩾100 nmol/l). There was an interaction between 25(OH)D concentration and gender in relation to CWP (interaction, p = 0.006), which was not fully explained by differences in lifestyle or social factors (adjusted interaction, p = 0.03). For women, the association between 25(OH)D concentration and CWP persisted after full adjustment (odds ratio (OR) for <75 nmol/l vs 75–99 nmol/l 1.57, 95% CI 1.09 to 2.26), while no evidence for an association was apparent in men (OR = 1.03, 95% CI 0.75 to 1.43). Conclusion: Current vitamin D status was associated with CWP in women but not in men. Follow-up studies are needed to evaluate whether higher vitamin D intake might have beneficial effects on the risk of CWP.
dc.identifier.citationAnnals of the Rheumatic Diseases, 2009; 68(6):817-822
dc.identifier.doi10.1136/ard.2008.090456
dc.identifier.issn0003-4967
dc.identifier.issn1468-2060
dc.identifier.urihttps://hdl.handle.net/1959.8/155439
dc.language.isoen
dc.publisherBMJ Group
dc.relation.fundingUK Medical Research Council G0000934
dc.relation.fundingBupa Foundation
dc.relation.fundingDepartment of Health (UK) Public Health Career Scientist Award
dc.relation.fundingDepartment of Health's National Institute of Health Research
dc.relation.fundingMedical Research Council
dc.rightsCopyright 2009 BMJ Publishing Group and European League Against Rheumatism
dc.source.urihttps://doi.org/10.1136/ard.2008.090456
dc.subjectchronic widespread pain
dc.subjectvitamin D
dc.subjectrisk factors
dc.subjectBritain
dc.subjectvitamin D deficiency
dc.titleVitamin D and chronic widespread pain in a white middle-aged British population: Evidence from a cross-sectional population survey
dc.typeJournal article
pubs.publication-statusPublished
ror.mmsid9915910668101831

Files

Collections