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Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host Defense to Streptococcus pneumoniae infection in mice: Role of the CCL2-CCR2 axis

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dc.contributor.authorWinter, C.
dc.contributor.authorTaut, K.
dc.contributor.authorSrivastava, M.
dc.contributor.authorLanger, F.
dc.contributor.authorMack, M.
dc.contributor.authorBriles, D.
dc.contributor.authorPaton, J.
dc.contributor.authorMaus, R.
dc.contributor.authorWelte, T.
dc.contributor.authorGunn, M.
dc.contributor.authorMaus, U.
dc.date.issued2007
dc.descriptionCopyright © 2007 by The American Association of Immunologists, Inc.
dc.description.abstractMononuclear phagocytes are critical components of the innate host defense of the lung to inhaled bacterial pathogens. The monocyte chemotactic protein CCL2 plays a pivotal role in inflammatory mononuclear phagocyte recruitment. In this study, we tested the hypothesis that increased CCL2-dependent mononuclear phagocyte recruitment would improve lung innate host defense to infection with Streptococcus pneumoniae. CCL2 transgenic mice that overexpress human CCL2 protein in type II alveolar epithelial cells and secrete it into the alveolar air space showed a similar proinflammatory mediator response and neutrophilic alveolitis to challenge with S. pneumoniae as wild-type mice. However, CCL2 overexpressing mice showed an improved pneumococcal clearance and survival compared with wild-type mice that was associated with substantially increased lung mononuclear phagocyte subset accumulations upon pneumococcal challenge. Surprisingly, CCL2 overexpressing mice developed bronchiolitis obliterans upon pneumococcal challenge. Application of anti-CCR2 Ab MC21 to block the CCL2-CCR2 axis in CCL2 overexpressing mice, though completely abrogating bronchiolitis obliterans, led to progressive pneumococcal pneumonia. Collectively, these findings demonstrate the importance of the CCL2-CCR2 axis in the regulation of both the resolution/repair and remodelling processes after bacterial challenge and suggest that overwhelming innate immune responses may trigger bronchiolitis obliterans formation in bacterial lung infections.
dc.description.statementofresponsibilityChristine Winter, Katharina Taut, Mrigank Srivastava, Florian Länger, Matthias Mack, David E. Briles, James C. Paton, Regina Maus, Tobias Welte, Michael D. Gunn and Ulrich A. Maus
dc.identifier.citationJournal of Immunology, 2007; 178(9):5828-5838
dc.identifier.doi10.4049/jimmunol.178.9.5828
dc.identifier.issn0022-1767
dc.identifier.issn1550-6606
dc.identifier.orcidPaton, J. [0000-0001-9807-5278]
dc.identifier.urihttp://hdl.handle.net/2440/43774
dc.language.isoen
dc.publisherAmer Assoc Immunologists
dc.source.urihttp://www.jimmunol.org/cgi/content/abstract/178/9/5828
dc.subjectLung
dc.subjectPhagocytes
dc.subjectBronchoalveolar Lavage Fluid
dc.subjectAnimals
dc.subjectMice, Transgenic
dc.subjectHumans
dc.subjectMice
dc.subjectStreptococcus pneumoniae
dc.subjectPneumococcal Infections
dc.subjectBronchiolitis Obliterans
dc.subjectReceptors, Chemokine
dc.subjectAntibodies, Monoclonal
dc.subjectCytokines
dc.subjectLigands
dc.subjectChemokine CCL2
dc.subjectReceptors, CCR2
dc.titleLung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host Defense to Streptococcus pneumoniae infection in mice: Role of the CCL2-CCR2 axis
dc.typeJournal article
pubs.publication-statusPublished

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