Precision genetic modification of the mammalian genome
Date
2000
Authors
Rathjen, Peter David
Verma, P. J.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Conference paper
Citation
Emerging technologies in agriculture: From ideas to adoption, 2000 / David H. White and James J. Walcott (eds.): pp.49-58
Statement of Responsibility
Conference Name
Abstract
The potential of transgenesis to achieve rational and efficient animal improvement has been recognised for some time.
Commercial application of this technology has been restricted by inherent limitations of existing methodologies, and a
shortage of candidate genes for transfer. Recent advances, notably in the areas of mammalian reproductive technologies and
whole genome sequencing, provide, for the first time, realistic prospects for directed genetic modification of the mammalian
genome in a commercially relevant manner. Augmentation of traditional breeding objectives with transgenic technologies can
be expected to improve the efficiency of existing breeding programs, while the opportunity to introduce novel genes and gene
combinations, and modify endogenous genes with precision, raises the possibility of developing animals with novel
properties, specifically designed for niche markets of enormous value.
Modification of the genome by transgenesis is therefore likely to become an important component of livestock industries.
While Australia has access to the relevant technologies, the pace of international progress has not been matched locally, and
this could compromise the competitiveness of local industries. Animal transgenesis provides an example of how strategic
investment in key emergent technologies at a local level can be critical for both the establishment and maintenance of
industries of international importance.
School/Discipline
School of Molecular and Biomedical Science