Mesenchymal stem cell-organized bone marrow elements: an alternative hematopoietic progenitor resource

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dc.contributor.authorMiura, Y.
dc.contributor.authorGao, Z.
dc.contributor.authorMiura, M.
dc.contributor.authorSeo, B.
dc.contributor.authorSonoyama, W.
dc.contributor.authorChen, W.
dc.contributor.authorGronthos, S.
dc.contributor.authorZhang, L.
dc.contributor.authorShi, S.
dc.date.issued2006
dc.description.abstractBone marrow-derived mesenchymal stem cells (BMMSCs) are multipotent postnatal stem cells that have been used for the treatment of bone defects and graft-versus-host diseases in clinics. In this study, we found that subcutaneously transplanted human BMMSCs are capable of organizing hematopoietic progenitors of recipient origin. These hematopoietic cells expressed multiple lineages of hematopoietic cell associated markers and were able to rescue lethally irradiated mice, with successful engraftment in the recipient, suggesting a potential bone marrow (BM) resource for stem cell therapies. Furthermore, we found that platelet-derived growth factor (PDGF) promotes the formation of BMMSC-generated BM niches through upregulation of β-catenin, implying that the PDGF pathway contributes to the formation of ectopic BM. These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value.
dc.description.statementofresponsibilityYasuo Miura, Zhigang Gao, Masako Miura, Byoung-Moo Seo, Wataru Sonoyama, Wanjun Chen, Stan Gronthos, Li Zhang, Songtao Shi
dc.identifier.citationStem Cells, 2006; 24(11):2428-2436
dc.identifier.doi10.1634/stemcells.2006-0089
dc.identifier.issn1066-5099
dc.identifier.issn1549-4918
dc.identifier.orcidGronthos, S. [0000-0002-6225-3084]
dc.identifier.urihttp://hdl.handle.net/2440/65982
dc.language.isoen
dc.publisherAlphamed Press
dc.rightsCopyright © 2006 AlphaMed Press
dc.source.urihttp://onlinelibrary.wiley.com/doi/10.1634/stemcells.2006-0089/abstract
dc.subjectMesenchymal stem cell
dc.subjectHematopoietic stem cell
dc.subjectPlatelet-derived growth factor
dc.subjectBone marrow organ system
dc.titleMesenchymal stem cell-organized bone marrow elements: an alternative hematopoietic progenitor resource
dc.typeJournal article
pubs.publication-statusPublished

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