Antibody immobilization within glass microstructured fibers: a route to sensitive and selective biosensors
Date
2008
Authors
Monro, T.
Ruan, Y.
Ebendorff-Heidepriem, H.
Foo, H.
Hoffmann, P.
Moore, R.
Editors
Sampson, D.
Collins, S.
Oh, K.
Yamauchi, R.
Collins, S.
Oh, K.
Yamauchi, R.
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Conference paper
Citation
19th International Conference on Optical Fibre Sensors, 15–18 April 2008, Perth, Australia / D. Sampson, S. Collins, K. Oh, R. Yamauchi (eds.): 70046Q
Statement of Responsibility
T.M. Monro, Y. Ruan, H. Ebendorff-Heidepriem, H. Foo, P. Hoffmann, R.C. Moore
Conference Name
International Conference on Optical Fibre Sensors (19th : 2008 : Perth, W. Aust.)
Abstract
Glass microstructured optical fibers have been rendered biologically active for the first time active via the immobilization of antibodies within the holes in the fiber cross-section. This has been done by introducing coating layers to the internal surfaces of soft glass fibers. The detection of proteins that bind to these antibodies has been demonstrated experimentally within this system via the use of fluorescence labeling. The approach combines the sensitivity resulting from the long interaction lengths of filled fibers with the selectivity provided by the use of antibodies.
School/Discipline
Dissertation Note
Provenance
Description
Access Status
Rights
Copyright © 2008, Society of Photo-Optical Instrumentation Engineers