Inulin isoforms differ by repeated additions of one crystal unit cell
| dc.contributor.author | Cooper, P.D. | |
| dc.contributor.author | Barclay, T.G. | |
| dc.contributor.author | Ginic Markovic, M. | |
| dc.contributor.author | Gerson, A.R. | |
| dc.contributor.author | Petrovsky, N. | |
| dc.date.issued | 2013 | |
| dc.description | Link to a related website: http://europepmc.org/articles/pmc4051881?pdf=render, Open Access via Unpaywall | |
| dc.description.abstract | Inulin isoforms, especially delta inulin, are important biologically as immune activators and clinically asvaccine adjuvants. In exploring action mechanisms, we previously found regular increments in thermalproperties of the seven-member inulin isoform series that suggested regular additions of some energetic structural unit. Because the previous isolates carried additional longer chains that masked definingranges, these were contrasted with new isoform isolates comprising only inulin chain lengths definingthat isoform. The new series began with 19 fructose units per chain (alpha-1 inulin), increasing regularlyby 6 fructose units per isoform. Thus the ‘energetic unit’ equates to 6 fructose residues per chain. Allisoforms showed indistinguishable X-ray diffraction patterns that were also identical with known inulincrystals. We conclude that an ‘energetic unit’ equates to one helix turn of 6 fructose units per chain asfound in one unit cell of the inulin crystal. Each isoform chain comprised progressively more helix turnsplus one additional fructose and glucose residues per chain. | |
| dc.identifier.citation | Carbohydrate Polymers, 2013; 103(1):392-397 | |
| dc.identifier.doi | 10.1016/j.carbpol.2013.12.066 | |
| dc.identifier.issn | 0144-8617 | |
| dc.identifier.issn | 1879-1344 | |
| dc.identifier.uri | https://hdl.handle.net/1959.8/154816 | |
| dc.language.iso | en | |
| dc.publisher | Pergamon-Elsevier Science Ltd | |
| dc.relation.funding | ARC LP0882596 | |
| dc.relation.funding | ARC LE0668489 | |
| dc.rights | Copyright 2014 Elsevier | |
| dc.source.uri | https://doi.org/10.1016/j.carbpol.2013.12.066 | |
| dc.subject | adjuvant | |
| dc.subject | carbohydrate | |
| dc.subject | inulin | |
| dc.subject | isoform | |
| dc.subject | polymorph | |
| dc.subject | vaccine | |
| dc.title | Inulin isoforms differ by repeated additions of one crystal unit cell | |
| dc.type | Journal article | |
| pubs.publication-status | Published | |
| ror.mmsid | 9915910008001831 |