Exploring relationships between host genome and microbiome: new insights from genome-wide association studies

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dc.contributor.authorAbdul-Aziz, M.
dc.contributor.authorCooper, A.
dc.contributor.authorWeyrich, L.
dc.contributor.editorBosch,Thomas C.,
dc.date.issued2016
dc.descriptionPublished: 12 October 2016
dc.description.abstractAs our understanding of the human microbiome expands, impacts on health and disease continue to be revealed. Alterations in the microbiome can result in dysbiosis, which has now been linked to subsequent autoimmune and metabolic diseases, highlighting the need to identify factors that shape the microbiome. Research has identified that the composition and functions of the human microbiome can be influenced by diet, age, sex, and environment. More recently, studies have explored how human genetic variation may also influence the microbiome. Here, we review several recent analytical advances in this new research area, including those that use genome-wide association studies to examine host genome–microbiome interactions, while controlling for the influence of other factors. We find that current research is limited by small sample sizes, lack of cohort replication, and insufficient confirmatory mechanistic studies. In addition, we discuss the importance of understanding long-term interactions between the host genome and microbiome, as well as the potential impacts of disrupting this relationship, and explore new research avenues that may provide information about the co-evolutionary history of humans and their microorganisms.
dc.description.statementofresponsibilityMuslihudeen A. Abdul-Aziz, Alan Cooper and Laura S. Weyrich
dc.identifier.citationFrontiers in Microbiology, 2016; 7(OCT):1611-1-1611-9
dc.identifier.doi10.3389/fmicb.2016.01611
dc.identifier.issn1664-302X
dc.identifier.issn1664-302X
dc.identifier.orcidAbdul-Aziz, M. [0000-0001-5600-0972]
dc.identifier.orcidCooper, A. [0000-0002-7738-7851]
dc.identifier.urihttp://hdl.handle.net/2440/101859
dc.language.isoen
dc.publisherFrontiers Media
dc.relation.granthttp://purl.org/au-research/grants/arc/DE150101574
dc.relation.granthttp://purl.org/au-research/grants/arc/FL140100260
dc.rightsCopyright © 2016 Abdul-Aziz,Cooper and Weyrich.This is an open-access article distributed under the terms of the Creative Commons Attribution License (CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s)or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.source.urihttp://journal.frontiersin.org/
dc.subjectmicrobiome; GWAS; ancient DNA; microbiome GWAS; model organisms; microbiota; symbiosis
dc.titleExploring relationships between host genome and microbiome: new insights from genome-wide association studies
dc.typeJournal article
pubs.publication-statusPublished

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